Image Quality Assessment of 2D versus 3D T2WI and Evaluation of Ultra-high b-Value (b=2,000 mm/s2) DWI for Response Assessment in Rectal Cancer
Image Quality Assessment of 2D versus 3D T2WI and Evaluation of Ultra-high b-Value (b=2,000 mm/s2) DWI for Response Assessment in Rectal Cancer
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DOI：
10.21873/anticanres.12311
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发表时间：
2018-02-01
影响因子：
2
通讯作者：
Attenberger, Ulrike I.
中科院分区：
文献类型：
--
作者：
Hausmann, Daniel;Liu, Jing;Attenberger, Ulrike I.
目的：本项IRB批准的回顾性研究旨在比较2D和高分辨率3D、T2加权（T2 WI）磁共振成像（MRI）序列的图像质量，并研究超高b值弥散加权成像（DWI; B= 2，000 mm/s（2））对直肠癌分期和评价治疗反应的附加价值。材料与方法：从2016年2月12日至8月24日，连续26例患者（22例男性，4例女性;平均年龄：61.9 ± 14.0岁）患有组织学证实的直肠癌。共纳入31项检查[ 12项在放化疗（CRT）前，19项在放疗后]。患者在3.0 T扫描仪（Magnetom Skyra，埃尔兰根，德国）上接受盆腔MRI。3名放射科医师（分别具有3、4和5年MRI经验）独立评估所有图像，并分别对每名患者的DWI（B=800 mm/s（2））、表观扩散系数图、DWI（B= 2，000 mm/s（2））、3D矢状T2 WI、3D轴向T2 WI、2D矢状T2 WI和2D轴向T2 WI的图像质量进行评级。此外，计算所有患者CRT后DWI（B= 2，000 mm/s（2））上直肠癌和闭孔内肌（背景）之间的信号强度比（SIR），并与组织病理学消退等级（RG）相关。结果如下：2DT 2 WI对肿瘤的显示优于3DT 2 WI（CRT前：Z=-3.2，p =0.02; CRT后：Z=-4.408，p = 0.05），且与3DT 2 WI比较差异有统计学意义（P < 0.05）。
Aim: The purpose of this IRB-approved, retrospective study was to compare image quality between 2D and high-resolution 3D, T2-weighted (T2WI) magnetic resonance imaging (MRI) sequences and to investigate the additional value of ultra-high b-value diffusion-weighted imaging (DWI; b=2,000 mm/s(2)) for both rectal cancer staging and evaluating treatment response. Materials and Methods: From 12 February to 24 August 2016, 26 consecutive patients (22 males, four females; mean age: 61.9 +/- 14.0 years) with histologically-proven rectal cancer. In total 31 examinations [ 12 prior to and 19 after chemoradiation (CRT)] were included. The patients underwent pelvic MRI on a 3.0-T scanner (Magnetom Skyra, Erlangen, Germany). Three radiologists (3, 4, and 5 years of experience in MRI, respectively) independently assessed all images and rated the image quality of DWI (b=800 mm/s(2)), apparent diffusion coefficient map, DWI (b=2,000 mm/s(2)), 3D sagittal T2WI, 3D axial T2WI, 2D sagittal T2WI, and 2D axial T2WI of each patient, respectively. In addition, signal intensity ratios (SIR) were calculated between rectal cancer and obturator internus muscle (background) in all patients after CRT on DWI (b=2,000 mm/s(2)) and correlated with histopathological regression grade (RG). Results: Tumor delineation was significantly better by 2D T2WI than 3D T2WI both before and after CRT (before CRT: Z=-3.2, p=0.02; after CRT: Z=-4.408, p