Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands
Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands
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DOI：
10.1172/jci0213880
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发表时间：
2002-01-01
影响因子：
15.9
通讯作者：
Farese, RV
中科院分区：
文献类型：
--
作者：
Chen, HC;Smith, SJ;Farese, RV
酰基 CoA：二酰基甘油酰基转移酶 (DGAT) 是一种普遍表达的酶，可催化甘油三酯合成主要途径中的最终反应。缺乏 DGAT1 (Dgat(-/-)) 的小鼠在包括皮肤在内的多个组织中表现出脂质代谢的显着变化。在这里，我们报告 DGAT1 缺乏对皮毛和皮脂腺的影响。成年Dgat(-/-)小鼠皮毛干燥和脱发，这与皮脂腺萎缩和皮毛脂质异常有关。结果，Dgat(-/-)小鼠在水浸后具有斥水性受损和温度调节缺陷。这些表型在瘦素缺乏的 Dgat(-/-) 小鼠中大多不存在，表明瘦素在调节皮肤表型方面具有意想不到的作用。我们的研究结果表明，DGAT1 在正常皮毛和皮脂腺生理学中发挥着重要作用，并提供了瘦素调节皮肤中这些过程的证据。
Acyl CoA:diacylglycerol acyltransferase (DGAT) is a ubiquitously expressed enzyme that catalyzes the final reaction in the major pathways of triglyceride synthesis. Mice lacking DGAT1 (Dgat(-/-)) demonstrate significant changes in lipid metabolism in several tissues, including the skin. Here we report the effects of DGAT1 deficiency on fur and sebaceous glands. Adult Dgat(-/-) mice had dry fur and hair loss, which were associated with atrophic sebaceous glands and fur lipid abnormalities. As a result, Dgat(-/-) mice had impaired water repulsion and defective thermoregulation after water immersion. These phenotypes were mostly absent in Dgat(-/-) mice with leptin deficiency, indicating an unexpected role for leptin in modulating the skin phenotype. Our findings indicate that DGAT1 plays an important role in normal fur and sebaceous gland physiology and provide evidence that leptin modulates these processes in the skin.