What's in a name: voxel-based morphometric analyses of MRI and naming difficulty in Alzheimer's disease, frontotemporal dementia and corticobasal degeneration
What's in a name: voxel-based morphometric analyses of MRI and naming difficulty in Alzheimer's disease, frontotemporal dementia and corticobasal degeneration
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DOI：
10.1093/brain/awh075
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发表时间：
2004-03-01
期刊：
影响因子：
14.5
通讯作者：
Gee, J
中科院分区：
文献类型：
--
作者：
Grossman, M;McMillan, C;Gee, J
对抗命名在神经退行性疾病中受损，如阿尔茨海默病（AD），额颞叶痴呆（FTD）和皮质基底节变性（CBD）。一些行为观察表明，这些患者群体的命名受损的共同来源，而其他人则发现部分独特的命名困难模式。我们假设，一个大规模的神经网络是命名的基础，AD，FTD和CBD的命名受损模式反映了皮质萎缩，这种萎缩以一种在这些患者群体中部分共享和部分独特的方式中断了这个网络。我们通过将命名障碍与50例患者结构MRI中皮质萎缩的基于体素的形态学（VBM）分析相关联来验证这一假设。我们在所有患者组中发现了显著的命名缺陷。在所有患者组（包括FTD患者亚组）中，词汇提取也与词汇提取相关。VBM分析显示，AD、FTD和CBD患者的左侧颞叶皮质均存在显著的皮质萎缩;该区域与所有组的命名准确性相关。因此，左侧颞叶萎缩似乎干扰了AD，FTD和CBD命名的词汇检索组件。命名受损还与特定患者组的语义记忆和视觉感知空间功能相关，相应地，命名与AD、FTD、CBD和FTD患者亚组中部分不同神经解剖分布的皮质萎缩相关。这些部分独特的相关配置文件似乎反映了选择性中断的其他组件的命名过程中，包括语义和视觉感知空间功能。这些发现与大规模神经网络支持命名的假设一致，并且在神经退行性疾病患者中，该网络以几种不同的方式中断。
Confrontation naming is impaired in neurodegenerative conditions like Alzheimer's disease (AD), frontotemporal dementia (FTD) and corticobasal degeneration (CBD). Some behavioural observations suggest a common source of impaired naming across these patient groups, while others find partially unique patterns of naming difficulty. We hypothesized that a large-scale neural network underlies naming, and that patterns of impaired naming in AD, FTD and CBD reflect cortical atrophy that interrupts this network in a manner that is partially shared and partially unique across these patient groups. We tested this hypothesis by correlating naming impairments with voxel-based morphometric (VBM) analyses of cortical atrophy in structural MRIs of 50 patients. We found significant naming deficits in all patient groups. Naming also correlated with lexical retrieval in all patient groups, including subgroups of patients with FTD. VBM analyses showed significant cortical atrophy, which was shared across AD, FTD and CBD patients in the left lateral temporal cortex; this area correlated with naming accuracy in all groups. Left lateral temporal atrophy thus appears to interfere with a lexical retrieval component of naming in AD, FTD and CBD. Impaired naming also correlated with semantic memory and visual perceptual-spatial functioning in specific groups of patients and, correspondingly, naming correlated with cortical atrophy in partially distinct neuroanatomical distributions in AD, FTD, CBD and subgroups of patients with FTD. These partially unique correlation profiles appear to reflect selective interruption of other components of the naming process, including semantic and visual perceptual-spatial functioning. These findings are consistent with the hypothesis that a large-scale neural network supports naming, and that this network is interrupted in several distinct ways in patients with neurodegenerative diseases.