Phosphorylated a-synuclein immunoreactivity in the posterior pituitary lobe
Phosphorylated a-synuclein immunoreactivity in the posterior pituitary lobe
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DOI：
10.1111/j.1440-1789.2011.01273.x
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发表时间：
2012-08-01
期刊：
影响因子：
2.3
通讯作者：
Mizutani, Toshio
中科院分区：
文献类型：
--
作者：
Homma, Taku;Mochizuki, Yoko;Mizutani, Toshio
帕金森病现在被认为是a-突触核蛋白病的一种主要形式，涉及中枢和周围神经系统。然而，尽管垂体后叶（PPL）在系统稳态中也起着重要作用，但尚未有研究关注该器官。在本研究中，我们旨在区分在路易体和非路易体相关疾病中观察到的PPL中磷酸化a-突触核蛋白（paSyn）阳性沉积。采用福尔马林固定石蜡包埋PPL标本对60例尸检病例的PaSyn沉积物进行免疫组织化学分析。在路易体相关疾病的病例中，几乎所有帕金森病（22/23）和1例伴路易体痴呆（1/1）均观察到PPL paSyn沉积。而在非路易体相关疾病中，PPL中仅有3/36例存在paSyn免疫反应性。本研究证实了pasyn阳性沉积物的存在，在帕金森病和伴路易体痴呆中均具有高特异性（97.1%）和高敏感性（88.5%），表明这一发现可作为路易体相关疾病的有用标志。
Parkinson's disease is now recognized as a major form of a-synucleinopathy involving both the central and peripheral nervous systems. However, no research has focused on the posterior pituitary lobe (PPL), despite the fact that this organ also plays an important role in systemic homeostasis. In the present study, we aimed to distinguish phosphorylated a-synuclein (paSyn)-positive deposits in the PPL, as is observed in Lewy body- and non-Lewy body-related disorders. PaSyn deposits were immunohistochemically analyzed using formalin-fixed, paraffin-embedded PPL specimens obtained from 60 autopsy cases. Among the cases with Lewy body-related disorders, PPL paSyn deposits were observed in almost all cases of Parkinson's disease (22/23), and in one case of dementia with Lewy bodies (1/1). On the other hand, only 3/36 cases of non-Lewy body-related disorders had paSyn immunoreactivity in the PPL. The present study confirms the presence of paSyn-positive deposits, as demonstrated by high specificity (97.1%) and sensitivity (88.5%), in both Parkinson's disease and dementia with Lewy bodies, suggesting that this finding can be a useful hallmark of Lewy body-related disorders.