Induction of transitional cell carcinomas of the urinary bladder in monkeys fed 2-naphthylamine.
Induction of transitional cell carcinomas of the urinary bladder in monkeys fed 2-naphthylamine.
复制标题
喂食 2-萘胺的猴子诱导膀胱移行细胞癌。
DOI：
10.1093/jnci/42.5.825
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发表时间：
1969
期刊：
影响因子：
--
通讯作者：
D. W. Crout
中科院分区：
文献类型：
--
作者：
G. Conzelman;J. Moulton;L. Flanders;K. Springer;D. W. Crout
24 只口服 2-萘胺的恒河猴中有 9 只在 60 个月内诱发膀胱移行细胞癌（最早的癌症为 33 个月）。肿瘤的范围从良性乳头状瘤延伸到浸润性癌。在一些动物的泌尿道中观察到除癌以外的病理学。口服剂量范围为6.25 mg/kg/天至400 mg/kg/天。尽管剂量反应关系很明显，但还是有一些无肿瘤的动物长期接受高剂量。另一方面，一些猴子接受了低剂量，但在尸检时出现了小肿瘤。尸检时检查的许多膀胱有多个病变。在某些情况下，同一膀胱中发现乳头状瘤、原位癌和浸润性癌。在 3 只患有阻塞性癌的动物中观察到肾积水。
Transitional cell carcinomas of the urinary bladder were induced within 60 months (earliest carcinoma, 33 months) in 9 of 24 rhesus monkeys given 2-naphthylamine orally. The spectrum of neoplasia extended from benign papilloma to invasive carcinoma. Pathology other than carcinoma was observed in the urinary tract of some animals. The oral dosage ranged from 6.25 mg/kg/day to 400 mg/kg/day. Although a dose-response relationship was apparent, there were tumor-free animals that received high doses for long periods. On the other hand, a few monkeys received low doses, but presented small tumors at necropsy. Many urinary bladders examined at autopsy had multiple lesions. In some cases, papilloma, carcinomain situ, and invasive carcinoma were found in the same bladder. Hydronephrosis was observed in 3 animals with obstructive carcinomas.