Cancer chemopreventive activity of the prenylated coumarin, umbelliprenin, in vivo
Cancer chemopreventive activity of the prenylated coumarin, umbelliprenin, in vivo
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DOI：
10.1097/cej.0b013e32832c389e
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发表时间：
2009-09-01
影响因子：
2.4
通讯作者：
Tokuda, Harukuni
中科院分区：
文献类型：
--
作者：
Iranshahi, Mehrdad;Sahebkar, Amirhossein;Tokuda, Harukuni
Umbelliprenin是一种异戊烯化的化合物，属于倍半萜香豆素类。在延续我们早期的体外发现中，我们决定通过使用由过氧亚硝酸盐作为引发剂和TPA（12-O-十四烷酰基佛波醇-13-乙酸酯）作为促进剂诱导的小鼠皮肤肿瘤的两阶段致癌试验来评估伞形酮在体内的癌症化学预防活性。在该试验中，用伞形科脂酶沿着过氧亚硝酸盐/TPA处理将乳头状瘤的形成延迟至第9周，并且在促进11周和20周后分别约33.3%和86.6%的小鼠患有乳头状瘤。与对照组相比，在20周的促进后，伞形科的每只小鼠的肿瘤数量减少了45%。有趣的是，这等于姜黄素的相应值（45%），在我们的研究中用作参考标准化合物。此外，与姜黄素相比，用umbelliprenin治疗的小鼠的肿瘤促进模式较慢。因此，umbeliprenin可能是一种有价值的癌症化学预防剂。欧洲癌症预防杂志18：412-415（C）2009年威科健康|利平科特威廉姆斯&威尔金斯。
Umbelliprenin is a prenylated compound, which belongs to the class of sesquiterpene coumarins. In continuation of our earlier in-vitro finding, we determined to assess the cancer chemopreventive activity of umbelliprenin in vivo by using a two-stage carcinogenesis assay of mouse skin tumors induced by peroxynitrite as an initiator and TPA (12-O-tetradecanoylphorbol-13-acetate) as a promoter. In this assay, treatment with umbelliprenin along with peroxynitrite/TPA delayed the formation of papillomas up to week 9, and approximately 33.3 and 86.6% of the mice bore papillomas after 11 and 20 weeks of promotion, respectively. Umbelliprenin reduced the number of tumors per mouse by 45% after 20 weeks of promotion compared with the control group. Interestingly, this is equal to the corresponding value (45%) for curcumin, used as a reference standard compound in our study. In addition, the pattern of tumor promotion was slower in mice treated with umbelliprenin compared with the curcumin. Therefore, umbelliprenin might be valuable as a cancer chemopreventive agent. European Journal of Cancer Prevention 18:412-415 (C) 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.