Oscillators in the microvasculature: glycocalyx and beyond.
Oscillators in the microvasculature: glycocalyx and beyond.
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微脉管系统中的振荡器：糖萼及其他。
DOI：
10.1152/ajpcell.00170.2022
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Goligorsky,MichaelS
中科院分区：
文献类型：
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作者：
Goligorsky,MichaelS
对生物系统中丰富的振荡功能的日益认识促使了这篇简短的概述，它缩小了微血管系统的范围。具体地说，它包括血流、红细胞压积和分叉处粘度的自我维持的振荡；血流对内皮细胞糖基化、机械转导的振荡的影响，以及为了随后的机械信号事件而终止到原始内皮细胞的影响；透明质酸-CD44结合域的振荡亲和力；皮质肌动蛋白网中肌球蛋白复合体的自发收缩及其对质膜张力的影响；sirtuin-1对内皮细胞糖基化的可逆作用；以及质膜张力对内和外吞的影响。讨论了这些振子之间的一些潜在相互作用以及它们之间的耦合，以及它们向混沌运动的转变。未来对微血管中振荡活动的深入了解可以为其在病理条件下的时序治疗提供指导。
The growing recognition of abundance of oscillating functions in biological systems has motivated this brief overview, which narrows down on the microvasculature. Specifically, it encompasses self-sustained oscillations of blood flow, hematocrit, and viscosity at bifurcations; blood flow effects on the oscillations of endothelial glycocalyx, mechanotransduction, and its termination to prime endothelial cells for the subsequent mechanical signaling event; oscillating affinity of hyaluronan-CD44 binding domain; spontaneous contractility of actomyosin complexes in the cortical actin web and its effects on the tension of the plasma membrane; reversible effects of sirtuin-1 on endothelial glycocalyx; and effects of plasma membrane tension on endo- and exocytosis. Some potential interactions between those oscillators, and their coupling, are discussed together with their transition into chaotic movements. Future in-depth understanding of the oscillatory activities in the microvasculature could serve as a guide to its chronotherapy under pathological conditions.