Physical sequelae and depressive symptoms in gynecologic cancer survivors: meaning in life as a mediator.
Physical sequelae and depressive symptoms in gynecologic cancer survivors: meaning in life as a mediator.
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妇科癌症幸存者的身体后遗症和抑郁症状：作为调解者的生活意义。
DOI：
10.1007/s12160-008-9029-8
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
Andersen,BarbaraL
中科院分区：
文献类型：
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作者：
Simonelli,LauraE;Fowler,Jeffrey;Maxwell,GLarry;Andersen,BarbaraL
癌症治疗后持续的症状和健康状况不佳可能会改变癌症幸存者的生活意义。妇科癌症幸存者特别受到身体后遗症的困扰。此外，对于最常见的疾病，如乳腺癌和妇科癌症，抑郁症的患病率也很高。PurposeThis study tests meaning in life as a mechanism for the relationship between physical symptoms and depression symptoms.MethodsGynecologic cancer survivors（N= 260）participated.在完成治疗后2-10年的常规临床随访访视时，获得身体后遗症（护士评定的症状/体征、患者报告的妇科症状）、生活意义（和谐、生活目的、灵性以及相反的困惑和失落）和抑郁症状的测量结果。潜变量进行了定义，结构方程模型测试的中介model.ResultsAnalyses支持部分调解。也就是说，幸存者与更多的身体后遗症也报告了较低水平的意义，在生活中，这是与更高水平的抑郁symptoms.ConclusionsGynecologic癌症患者被忽视的心理社会研究，研究结果突出存在的问题，在他们的生活中的重要性。虽然许多人适应得很好，但那些持续存在身体功能缺陷的人可能会出现抑郁症状。通过欣赏意义在他们的经历中的作用，我们可以帮助幸存者促进他们自己的成长和对他们未来重要的观点。
BackgroundContinuing symptoms and poor health following cancer treatments may alter meaning in life for cancer survivors. Gynecologic cancer survivors are particularly troubled with physical sequelae. In addition, for the most common sites of disease, such as breast and gynecologic cancers, the prevalence of depression is also high.PurposeThis study tests meaning in life as a mechanism for the relationship between physical symptoms and depressive symptoms.MethodsGynecologic cancer survivors (N= 260) participated. Measures of physical sequelae (nurse rated symptoms/signs, patient-reported gynecologic symptoms), meaning in life (harmony, life purpose, spirituality, and conversely, confusion and loss), and depressive symptoms were obtained at the time of a routine clinical follow-up visit 2–10 years following the completion of treatment. Latent variables were defined, and structural equation modeling tested a mediator model.ResultsAnalyses support partial mediation. That is, survivors with more physical sequelae also reported lower levels of meaning in life, which was associated with higher levels of depressive symptoms.ConclusionsGynecologic cancer patients have been neglected in psychosocial research, and findings highlight the importance of existential issues in their lives. While many adjust well, those with persistent physical functioning deficits may experience depressive symptoms. By appreciating the role of meaning in their experience, we may help survivors foster their own growth and perspectives important for their future.