Primary Cilia and Atherosclerosis.
Primary Cilia and Atherosclerosis.
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DOI：
10.3389/fphys.2021.640774
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发表时间：
2021
影响因子：
4
通讯作者：
Chen SL
中科院分区：
文献类型：
--
作者：
Wang ZM;Gao XF;Zhang JJ;Chen SL
在动脉树中，内皮功能与剪切应力（血液流动产生的牵引力）的分布相关。在层流剪切应力区域，内皮细胞（EC）可预防动脉粥样硬化，然而，受剪切应力干扰的部位的内皮细胞具有促炎症和动脉粥样硬化的特征。聚焦于 EC 机械传感器的剪切应力领域的基础研究引起了研究人员的兴趣。在所有已知的机械传感器中，初级纤毛是独特的，因为它在受干扰的剪应力区域丰富而在层流剪应力区域稀疏。初级纤毛是一种杆状的微细胞器，可以将细胞外的机械和化学刺激传递到细胞内空间。在心血管系统中，初级纤毛富含于受剪切应力干扰的区域，血流缓慢且振荡，例如心房、主动脉瓣下游、分支、分叉和动脉的内弯。然而，在房室管和直血管中，血流是层流的，初级纤毛几乎检测不到。心腔中的初级纤毛通过抑制转化生长因子 (TGF) 信号传导来防止 EC 发生间质转化和钙化。此外，血管内皮中的初级纤毛通过触发 Ca2+ 流入以及一氧化氮 (NO) 释放，保护内皮细胞免受剪切应力干扰引起的细胞损伤。此外，初级纤毛抑制动脉粥样硬化的过程。在当前的综述中，我们讨论了纤毛发生、纤毛结构以及纤毛分布、功能以及心血管系统中剪应力的协调信号转导。
In artery tree, endothelial function correlates with the distribution of shear stress, a dragging force generated by flowing blood. In laminar shear stress areas, endothelial cells (ECs) are available to prevent atherosclerosis, however, ECs in disturbed shear stress sites are featured with proinflammation and atherogenesis. Basic studies in the shear stress field that focused on the mechanosensors of ECs have attracted the interest of researchers. Among all the known mechanosensors, the primary cilium is distinctive because it is enriched in disturbed shear stress regions and sparse in laminar shear stress areas. The primary cilium, a rod liked micro-organelle, can transmit extracellular mechanical and chemical stimuli into intracellular space. In the cardiovascular system, primary cilia are enriched in disturbed shear stress regions, where blood flow is slow and oscillatory, such as the atrium, downstream of the aortic valve, branches, bifurcations, and inner curves of the artery. However, in the atrioventricular canal and straight vessels, blood flow is laminar, and primary cilia can barely be detected. Primary cilia in the heart cavity prevent ECs from mesenchymal transition and calcification by suppressing transforming growth factor (TGF) signaling. Besides, primary cilia in the vascular endothelium protected ECs against disturbed shear stress-induced cellular damage by triggering Ca2+ influx as well as nitric oxide (NO) release. Moreover, primary cilia inhibit the process of atherosclerosis. In the current review, we discussed ciliogenesis, ciliary structure, as well as ciliary distribution, function and the coordinate signal transduction with shear stress in the cardiovascular system.
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影响因子：
--
作者：
Hsiao YC;Tuz K;Ferland RJ
通讯作者：
Ferland RJ
DOI：
10.1161/hypertensionaha.111.172080
发表时间：
2011-08
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Abdul-Majeed S;Nauli SM
通讯作者：
Nauli SM
影响因子：
20.1
作者：
Egorova AD;Khedoe PP;Goumans MJ;Yoder BK;Nauli SM;ten Dijke P;Poelmann RE;Hierck BP
通讯作者：
Hierck BP
影响因子：
11
作者：
Hsieh HJ;Liu CA;Huang B;Tseng AH;Wang DL
通讯作者：
Wang DL
影响因子：
3.3
作者：
Chapin HC;Rajendran V;Caplan MJ
通讯作者：
Caplan MJ