Comparative study of tear lipid composition in two human populations with different exposure to particulate matter in La Plata, Argentina
Comparative study of tear lipid composition in two human populations with different exposure to particulate matter in La Plata, Argentina
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DOI：
10.1007/s11356-019-04134-0
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发表时间：
2019-03-01
影响因子：
5.8
通讯作者：
Andrinolo, Dario
中科院分区：
文献类型：
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作者：
de los Angeles Gutierrez, Maria;Colman Lerner, Jorge Esteban;Andrinolo, Dario
通过气相色谱-质谱（GC-MS）检测，确定暴露于不同水平颗粒物质的两个人群泪膜脂质谱的变化及其与干眼症的关系。一项涉及78名志愿者的小组研究，他们生活和工作在阿根廷两个不同污染水平的地方：城市区（n=44）和工业区（n=34）。我们测量了颗粒物（PM）暴露的平均水平。采用气相色谱-质谱联用仪检测泪液样本，并采用Schirmer试验、荧光素破裂时间、荧光素和丽丝胺绿色活体染色以及眼睑平行结膜皱褶（LIPCOF）诊断干眼。使用卡方检验、Bartlett检验、Mann-Whitney检验和多重对应分析进行统计学分析。工业区PM10浓度显著高于市区（p
To identify the changes in the lipid profile of the tear film in two human populations exposed to different levels of particulate material, and its relationship with dry eye, by gas chromatography with mass spectrometry (GC-MS) detection. A panel study involving 78 volunteers, who live and work in two locations in Argentina with different pollution levels: urban zone (n=44) and industrial zone (n=34). We measured the mean levels of particulate matter (PM) exposure. The tear samples were analyze by gas GC-MS detection and the dry eye was diagnose using Schirmer test, fluorescein breakup time, vital staining with fluorescein and lissamine green, and lid parallel conjunctival folds (LIPCOF). Statistical analysis was performed using Chi-Square, Bartlett's, Mann-Whitney tests, and Multiple Correspondence Analysis. PM10 level was significantly higher in industrial zone than in urban area (p