Antioxidant nutrients and pulmonary function: The Third National Health and Nutrition Examination Survey (NHANES III)
Antioxidant nutrients and pulmonary function: The Third National Health and Nutrition Examination Survey (NHANES III)
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DOI：
10.1093/oxfordjournals.aje.a010141
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发表时间：
2000-05-15
影响因子：
5
通讯作者：
Cassano, PA
中科院分区：
文献类型：
--
作者：
Hu, GZ;Cassano, PA
最近对慢性阻塞性肺疾病的研究引起了人们对其与营养关系的兴趣。在健康的一般人群样本中，几种膳食抗氧化剂与肺功能呈正相关。这项研究考虑了维生素 C、维生素 E、β-胡萝卜素和硒摄入量的单独和联合影响，并使用了饮食评估和抗氧化状态的血清生物标志物。作者使用了第三次全国健康和营养检查调查的数据，该调查包含 1988 年至 1994 年美国人口的样本代表（n = 18,162 名年龄大于或等于 17 岁的受试者）。多元线性回归分析检查了抗氧化剂对调整协变量后第一秒用力呼气量 (FEV1)/身高 (2) 的比率的单独和联合影响。每种膳食和血清抗氧化营养素均与 FEV1 显着相关。当同时考虑它们时（在单独的模型中考虑饮食和血清变量），大多数营养素都观察到独立关联。吸烟者血清 β-胡萝卜素与 FEV1 的正相关性低于不吸烟者，而吸烟者血清硒与 FEV1 的正相关性更强。作者发现，较高水平的抗氧化营养素与更好的肺功能相关。抗氧化剂与肺功能的总体关联性以及这种关联性是否因吸烟状况而变化的发现对进一步的研究具有重要意义。
Recent studies of chronic obstructive pulmonary disease have raised interest in its relation to nutrition. Several dietary antioxidants have been positively associated with lung function in healthy, general population samples. This study considered the separate and joint effects of vitamin C, vitamin E, beta-carotene, and selenium intake and used both dietary assessment and serum biomarkers of antioxidant status. The authors used data from the Third National Health and Nutrition Examination Survey comprising a sample representative of the US population in 1988-1994 (n = 18,162 subjects aged greater than or equal to 17 years). Multiple linear regression analysis examined the separate and joint effects of the antioxidants on the ratio of forced expiratory volume in the first second (FEV1)/height(2) adjusted for covariates. Each of the dietary and serum antioxidant nutrients was significantly associated with FEV1. When they were considered simultaneously (dietary and serum variables considered in separate models), independent associations were observed for most nutrients. Serum beta-carotene was less positively associated with FEV1 in smokers than nonsmokers, while serum selenium had a stronger positive association with FEV1 in smokers. The authors found that higher levels of antioxidant nutrients are associated with better lung function. The finding that the antioxidants differ in both their overall association with lung function and in whether this association varies by smoking status has implications for further research.