CYTOGENETIC FINDINGS IN 200 PATIENTS WITH MULTIPLE-MYELOMA
CYTOGENETIC FINDINGS IN 200 PATIENTS WITH MULTIPLE-MYELOMA
复制标题
DOI：
10.1016/0165-4608(94)00284-i
复制
发表时间：
1995-07-01
影响因子：
--
通讯作者：
BARLOGIE, B
中科院分区：
文献类型：
--
作者：
SAWYER, JR;WALDRON, JA;BARLOGIE, B
对200例多发性骨髓瘤及相关疾病患者进行了细胞遗传学研究。在63名患者（32%）中发现了结构或数量异常的克隆，包括45名未治疗患者中的8名（18%）和155名治疗患者中的55名（35%）。异常核型多表现为数目和结构异常，部分患者有多个异常克隆。超二倍体核型患者最显著的特征是发现3、5、7、9、11、15、19和21号染色体的重复性三体，在许多情况下一起共分离。13号染色体单体性是最常见的染色体丢失，发生在18例异常患者（29%）中，而涉及13 q14带的间质缺失发生在另外9例患者中，表明在高比例的异常核型患者（43%）中13号染色体的全部或部分丢失。1号染色体的结构畸变最常见，发生在63例患者中的30例（48%），并且几乎同样涉及短臂和长臂。最常见的染色体断裂点涉及14 q32带，见于21例患者（33%），包括11例14 q+染色体，8例t（11;14）（q13;q32），2例t（8;14）（q24;q32）。
Cytogenetic studies were performed on 200 consecutive patients with multiple myeloma and related disorders. Structurally or numerically abnormal clones were found in 63 patients (32%), including 8 of 45 untreated patients (18%), and 55 of 155 treated patients (35%). The abnormal karyotypes generally showed numerous numerical and structural aberrations and in some patients multiple abnormal clones. The most striking feature of patients with hyperdiploid karyotypes was the finding of consistent recurring trisomies for chromosomes 3, 5, 7, 9, 11, 15, 19, and 21, cosegregating together in many cases. Monosomy for chromosome 13 was the most common chromosome loss, occurring in 18 abnormal patients (29%), while interstitial deletions involving band 13q14 occurred in an additional 9 patients, indicating a loss of all or part of chromosome 13 in a high percentage of patients with abnormal karyotypes (43%). Structural aberrations of chromosome 1 were most frequent, occurring in 30 of 63 patients (48%), and involved almost equally the short and long arms. The single most frequent chromosome breakpoint involved band 14q32 and was found in 21 patients (33%), including 11 patients with a 14q+ chromosome, 8 with t(11;14)(q13;q32), and 2 with t(8;14)(q24;q32).