Short- and Long-Term Effects of Ambient Ozone and Fine Particulate Matter on the Respiratory Health of Chronic Obstructive Pulmonary Disease Subjects
Short- and Long-Term Effects of Ambient Ozone and Fine Particulate Matter on the Respiratory Health of Chronic Obstructive Pulmonary Disease Subjects
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DOI：
10.1080/19338244.2014.932753
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发表时间：
2015-01-02
影响因子：
1.8
通讯作者：
Wilkins, J. R., III
中科院分区：
文献类型：
--
作者：
Kariisa, Mbabazi;Foraker, Randi;Wilkins, J. R., III
到目前为止，还没有研究评估空气污染暴露对接受肺减容手术(LVRS)的肺气肿患者的短期和长期影响。全国肺气肿治疗试验研究(1998-2003)的数据包括1,218名受试者，年龄在39岁到84岁之间。获得了环境细颗粒物(空气动力学直径；2.5微米；PM2.5)和臭氧的日平均值。混合效应模型测试了短期和长期污染物浓度与肺功能变化之间的关联。累积的空气污染暴露与呼吸功能和症状的恶化密切相关。PM2.5的平均值与较差的肺功能相关。暴露时间过长与呼吸健康结果的相关性很差。在研究参与者中观察到，即使环境空气污染物水平很低，也会产生有害的呼吸系统和肺部影响。这些结果表明，即使暴露在低于空气质量标准的环境中，仍可能对严重的慢性阻塞性肺疾病(COPD)患者构成重大风险。
To date, no study has evaluated the short- and long-term effects air pollution exposure on emphysematous subjects who have undergone lung volume reduction surgery (LVRS). Data from the National Emphysema Treatment Trial study (1998-2003) included 1,218 subjects, aged 39 to 84. Daily values of ambient fine particulate matter (aerodynamic diameter < 2.5 mu m; PM2.5) and ozone were obtained. Mixed-effects models tested the association between short- and long-term pollutant concentrations and changes in pulmonary function. Cumulative air pollution exposure was strongly associated with worsened respiratory function and symptoms. Mean PM2.5 was associated with poorer lung function. Lagged exposures were poorly associated with respiratory health outcomes. There were detrimental respiratory and pulmonary effects observed in response to even low levels of ambient air pollutants among study participants. These results are indicative that exposures even below those of air quality standards may still pose significant risks to severe chronic obstructive pulmonary disease (COPD) subjects.