The role of sulcular environment in controlling epithelial keratinization.
The role of sulcular environment in controlling epithelial keratinization.
复制标题
龈沟环境在控制上皮角化中的作用。
DOI：
10.1902/jop.1979.50.1.1
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发表时间：
1979
影响因子：
4.3
通讯作者：
W. Castelli
中科院分区：
文献类型：
--
作者：
R. Caffesse;C. Nasjleti;W. Castelli
本文以3只年轻成年恒河猴为实验对象，研究了口腔黏膜环境对牙龈外表面上皮角化的影响。将40个粘骨膜瓣抬高，倒置，使外表面上皮与牙齿接触，缝合。实验时间间隔从1小时到60天不等。猴子在献祭前1小时注射H3胸腺嘧啶。准备材料进行组织学和放射自显影评价。结果表明，当与牙齿近距离接触时，外表面上皮形态转变为无深网钉的非角化上皮，具有通常在沟状上皮中看到的解剖特征。由此可见，龈沟环境对龈外表面上皮的角化电位具有控制作用。这进一步表明，细菌菌斑及其产物的持续刺激可能是导致管状上皮过早脱屑的原因，而这反过来又可能使其无法完全分化。
The influence of the sulcular environment on the keratinization of the outer surface gingival epithelium was tested in three young adult Rhesus monkeys. A total of 40 mucoperiosteal flaps were raised, and inverted so as to bring the outer surface epithelium in contact with the tooth, and were sutured. The experimental time intervals varied from 1 hour to 60 days. The monkeys received H3 thymidine 1 hour prior to sacrifice. The material was prepared for histologic and radioautographic evaluation. Results indicated that the outer surface epithelium changes its morphology to a nonkeratinized epithelium devoid of deep rete pegs when in close contact with the tooth, resulting in the anatomical characteristics normally seen in sulcular epithelium. It is concluded that the sulcular environment has the capability of controlling the keratinizing potential of the outer surface gingival epithelium. It is further suggested that the constant irritation of bacterial plaque and its products may be responsible for the premature desquamation of the sulcular epithelium which in turn might not allow its full differentiation.