Role of AT2 receptor in the brain in regulation of blood pressure and water intake
Role of AT2 receptor in the brain in regulation of blood pressure and water intake
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DOI：
10.1152/ajpheart.00515.2002
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发表时间：
2003-01-01
影响因子：
4.8
通讯作者：
Horiuchi, M
中科院分区：
文献类型：
--
作者：
Li, Z;Iwai, M;Horiuchi, M
利用血管紧张素Ⅱ受体缺陷小鼠，观察了侧脑室注射血管紧张素Ⅱ（ANG Ⅱ）对血压和饮水量的影响。在野生型（WT）小鼠和ANG 2型AT（2）受体敲除（AT（2）KO）小鼠中，ICV注射ANG II以剂量依赖性方式增加收缩压;然而，AT（2）KO小鼠的这种增加明显大于WT小鼠。在WT小鼠中，对中枢注射ANG II的升压反应被ICV预注射选择性AT（1）受体阻断剂缬沙坦抑制，但被AT（2）受体阻断剂PD-123319放大。ICV注射ANG II也增加了饮水量。在AT（2）KO和AT（1）aKO小鼠中，它都被部分但显著地抑制。AT（2）/AT（1）aKO小鼠的水摄入对ICV注射ANG II没有反应。缬沙坦和PD-123319均部分抑制WT小鼠的饮水量。这些结果表明，中枢AT（1）a和AT（2）受体在血压调节中具有拮抗作用，但它们在调节ANG II诱导的饮水量方面具有协同作用。
The effects of intracerebroventricular (ICV) injection of angiotensin II (ANG II) on blood pressure and water intake were examined with the use of ANG II receptor-deficient mice. ICV injection of ANG II increased systolic blood pressure in a dose-dependent manner in wild-type (WT) mice and ANG type 2 AT(2) receptor null (knockout) (AT(2)KO) mice; however, this increase was significantly greater in AT(2)KO mice than in WT mice. The pressor response to a central injection of ANG II in WT mice was inhibited by ICV preinjection of the selective AT(1) receptor blocker valsartan but exaggerated by the AT(2) receptor blocker PD-123319. ICV injection of ANG II also increased water intake. It was partly but significantly suppressed both in AT(2)KO and AT(1)aKO mice. Water intake in AT(2)/AT(1)aKO mice did not respond to ICV injection of ANG II. Both valsartan and PD-123319 partly inhibited water intake in WT mice. These results indicate an antagonistic action between central AT(1)a and AT(2) receptors in the regulation of blood pressure, but they act synergistically in the regulation of water intake induced by ANG II.