Birth Regulates the Initiation of Sensory Map Formation through Serotonin Signaling
Birth Regulates the Initiation of Sensory Map Formation through Serotonin Signaling
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DOI：
10.1016/j.devcel.2013.09.002
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发表时间：
2013-10-14
影响因子：
11.8
通讯作者：
Kawasaki, Hiroshi
中科院分区：
文献类型：
--
作者：
Toda, Tomohisa;Homma, Daigo;Kawasaki, Hiroshi
虽然感觉地图的空间模式形成的机制已被广泛研究，在发展过程中触发感觉地图的形成在很大程度上是未知的。在这里，我们表明，出生的幼崽连续性和选择性地调节启动桶形成的躯体感觉皮层，通过降低血清素浓度。我们发现，早产加速桶的形成，而它并不影响桶状体的形成或桶结构的可塑性。我们还发现，血清素在出生后不久就选择性地减少，而且血清素的减少是由出生引发的。5-羟色胺的减少对于出生对桶形结构的影响是必要和充分的。有趣的是，这里描述的调节机制也被发现可以调节视觉系统中眼睛特异性的分离，这表明它们在不同的大脑区域中被利用。我们的研究结果揭示了出生和血清素在感觉地图形成中的作用。
Although the mechanisms underlying the spatial pattern formation of sensory maps have been extensively investigated, those triggering sensory map formation during development are largely unknown. Here we show that the birth of pups instructively and selectively regulates the initiation of barrel formation in the somatosensory cortex by reducing serotonin concentration. We found that preterm birth accelerated barrel formation, whereas it did not affect either barreloid formation or barrel structural plasticity. We also found that serotonin was selectively reduced soon after birth and that the reduction of serotonin was triggered by birth. The reduction of serotonin was necessary and sufficient for the effect of birth on barrel formation. Interestingly, the regulatory mechanisms described here were also found to regulate eye-specific segregation in the visual system, suggesting that they are utilized in various brain regions. Our results shed light on roles of birth and serotonin in sensory map formation.