Astrovirus Pathogenesis.
Astrovirus Pathogenesis.
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DOI：
10.3390/v9010022
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发表时间：
2017-01-22
期刊：
影响因子：
--
通讯作者：
Schultz-Cherry S
中科院分区：
文献类型：
--
作者：
Johnson C;Hargest V;Cortez V;Meliopoulos VA;Schultz-Cherry S
星状病毒是年轻人、老年人和免疫功能低下者腹泻的主要原因。自1975年发现人类星状病毒1型（HAstV-1）以来，星状病毒科已经扩展到包括两个人类分支和许多哺乳动物和鸟类特异性基因型。尽管如此，对发病机制仍知之甚少。下面的审查强调了目前的知识，星状病毒的发病机制，并概述了进一步的星状病毒的研究，包括细胞培养系统的动物模型的发展所需的关键步骤。
Astroviruses are a major cause of diarrhea in the young, elderly, and the immunocompromised. Since the discovery of human astrovirus type 1 (HAstV-1) in 1975, the family Astroviridae has expanded to include two more human clades and numerous mammalian and avian-specific genotypes. Despite this, there is still little known about pathogenesis. The following review highlights the current knowledge of astrovirus pathogenesis, and outlines the critical steps needed to further astrovirus research, including the development of animal models of cell culture systems.