Targeted gene disruption of the prostaglandin E2 EP2 receptor.
Targeted gene disruption of the prostaglandin E2 EP2 receptor.
复制标题
DOI：
10.1007/978-1-4615-0193-0_49
复制
发表时间：
2002
影响因子：
--
通讯作者：
R. Breyer;C. Kennedy;Yahua Zhang;Y. Guan;M. Breyer
中科院分区：
文献类型：
--
作者：
R. Breyer;C. Kennedy;Yahua Zhang;Y. Guan;M. Breyer
前列腺素是一种由花生四烯酸环氧化酶（COX）代谢生成PGG/H2的类自传素家族，可生成5种主要的生物活性前列腺素代谢产物：PGE2、PGF2a、PGD2、PGI2和TXA2 1。PGs在广泛的生理活动中发挥作用，包括调节炎症、排卵和动脉血压。这些PG代谢物至少在一定程度上通过与不同的g蛋白偶联受体（gpcr） 2相互作用发挥作用，每种gpcr都具有不同的配体选择性和信号转导途径。
Prostaglandins comprise a diverse family of autacoids derived from cyclooxygenase (COX) metabolism of arachidonic acid to PGG/H2, leading to the generation of five principal bio-active prostaglandin (PG) metabolites: PGE2, PGF2a, PGD2, PGI2, and TXA2 1. The PGs play a role in a broad range of physiologic activities including modulating inflammation, ovulation and arterial blood pressure. These PG metabolites exert their effects at least in part by interacting with distinct G-protein coupled receptors (GPCRs) 2, each with distinct ligand selectivity and signal transduction pathways.