Technique of successful lung transplantation in humans.
Technique of successful lung transplantation in humans.
复制标题
成功进行人体肺移植的技术。
DOI：
10.1016/s0022-5223(19)36439-6
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
W.A.P. DeMajo
中科院分区：
文献类型：
--
作者：
Joel D. Cooper;F. Pearson;G. Patterson;T. Todd;Robert J. Ginsberg;M. Goldberg;W.A.P. DeMajo
我们为终末期肺纤维化患者进行了5例单肺移植，其中4例长期存活。2例患者行右肺移植，2例行左肺移植。手术是在单肺麻醉下进行的，但如果需要，也可以在待机状态下使用体外循环。供者和受者的手术在相邻的手术室进行。在实验室研究的基础上，完成后在支气管吻合口周围包裹带蒂大网膜，以恢复支气管动脉的循环，保护吻合口。4名患者在4至6周内出院，3名患者在3个月后恢复正常工作。这些病例的成功归功于仔细的患者选择，环孢素的使用，以及使用大网膜蒂来保护和改善支气管吻合口的愈合。
We have performed five single lung transplantations for end-stage pulmonary fibrosis, with four long-term survivors. Two patients underwent right lung transplantation and two underwent left lung transplantation. The procedure is performed with one lung anesthesia, although cardiopulmonary bypass is available on standby if required. Donor and recipient procedures are performed in adjacent operating rooms. On the basis of laboratory studies, a pedicle of omentum is wrapped around the bronchial anastomosis after its completion to restore bronchial artery circulation and protect the anastomosis. The four patients were discharged from the hospital within 4 to 6 weeks and three returned to normal employment at 3 months. Success in these cases is attributed to careful patient selection, use of cyclosporine, and use of an omental pedicle to protect and improve healing of the bronchial anastomosis.