Relationship of Neutrophil-to-Lymphocyte Ratio with Aortic Stiffness in Type 1 Diabetes Mellitus
Relationship of Neutrophil-to-Lymphocyte Ratio with Aortic Stiffness in Type 1 Diabetes Mellitus
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DOI：
10.1016/j.jcjd.2015.01.004
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发表时间：
2015-08-01
影响因子：
2.5
通讯作者：
Bozkurt, Engin
中科院分区：
文献类型：
--
作者：
Ayhan, Huseyin;Kasapkara, Haci Ahmet;Bozkurt, Engin
目的：新出现的证据表明，嗜中性粒细胞与淋巴细胞比率（NLR）可能是炎症和主动脉僵硬的有用标志物。炎症标志物和主动脉僵硬度都是心血管事件的指标。因此，我们研究了NLR是否与1型糖尿病患者的主动脉僵硬度相关。方法：我们研究了76例1型糖尿病患者和36例健康对照者的NLR与主动脉僵硬度的关系。1型糖尿病组的NLR高于对照组（分别为2.33 ± 0.95 vs. 1.80 ± 0.68; p = 0.003）。与对照组相比，患者组的主动脉张力和主动脉扩张性，即通过超声心动图无创测量的主动脉僵硬度参数，显著降低（8.0% ± 1.5% vs. 13.1% ± 3.3%; p
Objectives: Emerging evidence suggests that the neutrophil-to-lymphocyte ratio (NLR) may be a useful marker of inflammation and aortic stiffness. Markers of inflammation and aortic stiffness are both indicators of cardiovascular events. We, therefore, investigated whether the NLR is associated with aortic stiffness in patients with type 1 diabetes mellitus.Methods: We examined the relationship of the NLR to aortic stiffness in 76 people with type 1 diabetes and 36 healthy controls.Results: The NLRs in the group with type 1 diabetes were higher than in the controls (2.33 +/- 0.95 vs. 1.80 + 0.68, respectively; p = 0.003). Aortic strain and aortic distensibility, the parameters of aortic stiffness, measured noninvasively by the help of echocardiography, were significantly decreased in the patient group compared to controls (8.0% +/- 1.5% vs. 13.1% +/- 3.3 %; p