Identification and characterization of the actinomycin G gene cluster in Streptomyces iakyrus
Identification and characterization of the actinomycin G gene cluster in Streptomyces iakyrus
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链霉菌中放线菌素 G 基因簇的鉴定和表征。
DOI：
10.1039/c3mb70081j
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发表时间：
2013-01-01
影响因子：
--
通讯作者：
Deng, Hai
中科院分区：
文献类型：
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作者：
Wang, Xiaoling;Tabudravu, Jioji;Deng, Hai
对链霉菌放线菌素G生物合成的基因簇进行了鉴定和测序。它含有一个放线菌素合成酶I（ACMS I）基因和两个ACMS II和III基因拷贝。遗传分析表明，acmG 8和acmG 9基因需要分别转录用于放线菌素G2-3的生物合成，因此推测的羟基化和氯化活性之间存在独特的伙伴关系。
The gene cluster directing actinomycin G biosynthesis in Streptomyces iakyrus has been identified and sequenced. It contains one actinomycin synthetase I (ACMS I) gene and two copies of ACMS II and III genes. Genetic analysis demonstrates a unique partnership between the putative hydroxylation and chlorination activities as both acmG8 and acmG9 genes need to be transcribed for the biosynthesis of actinomycin G2-3, respectively.