The acquisition of lipids by African trypanosomes.
The acquisition of lipids by African trypanosomes.
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非洲锥虫获取脂质。
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
A. Samad
中科院分区：
文献类型：
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作者：
A. Mellors;A. Samad
非洲锥虫的血液形态依赖于它们的宿主，以获得脂肪酸、胆碱和其他膜脂成分。他们对胆碱的大部分需求是由他们从宿主组织液中吸收溶血磷脂的能力来满足的。布氏锥虫具有辛基转移糖和磷脂酶A(1)活性，可用于外源溶血磷脂的代谢。溶血磷脂的摄取速度可以通过细胞外脂肪酰基辅酶A浓度的变化来控制，这种控制有可能用于化疗。
Bloodstream forms of African trypanosomes are dependent on their host for fatty acids, choline and other components of membrane lipids. The bulk of their choline requirement is met by their ability to take up lysophospholipids from the host tissue fluids. Trypanosoma brucei has ocyltransferose and phospholipase A(1) activities for the metabolism of exogenous lysophospholipids. The rate of uptake of lysophospholipids can be controlled by changes in the extrocellulor concentration of fatty ocyl-coenzyme A, and this control has potential for chemotherapy.