VEGF is causative for pulmonary hypertension in a patient with Crow-Fukase (POEMS) syndrome.
VEGF is causative for pulmonary hypertension in a patient with Crow-Fukase (POEMS) syndrome.
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VEGF 是 Crow-Fukase (POEMS) 综合征患者肺动脉高压的原因。
DOI：
10.2169/internalmedicine.39.1101
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发表时间：
2000
影响因子：
1.2
通讯作者：
I. Kitajima
中科院分区：
文献类型：
--
作者：
H. Niimi;K. Arimura;M. Jonosono;T. Hashiguchi;M. Kawabata;M. Osame;I. Kitajima
我们报告一例crowo - fukase （POEMS）综合征合并肺动脉高压（PH）。本例患者血清中血管内皮生长因子（VEGF）浓度极高，既往报道认为是crowo - fukase综合征PH调节因子的il -1 β、IL-6、tnf - α和硫胺素水平正常。强的松龙治疗后，PH消失，血清VEGF显著降低。我们的结果表明，在crowo - fukase综合征中，VEGF与PH密切相关。
We report a case of Crow-Fukase (POEMS) syndrome associated with pulmonary hypertension (PH). In this case, the concentration of vascular endothelial growth factor (VEGF) was extremely high in the serum, and the levels of IL-1beta, IL-6, TNF-alpha, and thiamine, which were thought in past reports to be mediators of PH in Crow-Fukase syndrome, were normal. After prednisolone therapy, PH disappeared with a dramatic decrease in serum VEGF. Our results suggest that VEGF is closely correlated with PH in Crow-Fukase syndrome.