IL-12Bpro and GSTP1 polymorphisms in association with silicosis
IL-12Bpro and GSTP1 polymorphisms in association with silicosis
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DOI：
10.1111/j.1399-0039.2007.00985.x
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发表时间：
2008-02-01
期刊：
影响因子：
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通讯作者：
Prakova, G.
中科院分区：
文献类型：
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作者：
Stanilova, S.;Miteva, L.;Prakova, G.
为了评估IL- 12bpro和GSTP1多态性在诱导的白细胞介素(IL)-12p40产生与矽肺发展中的作用，我们检测了它们在63名矽肺患者和165名健康供体中的分布。与暴露的健康供者相比，患者IL-12Bpro-2等位基因（42%比62.5%,P = 0.0042）和基因型22（19%比40%，P = 0.02）的频率降低，提示其在矽肺易感性中起保护作用。GSTP1 A/G多态性也与矽肺易感性相关。等位基因G和基因型GG在患者中的比例高于健康男性（36%比23%，P = 0.013； 14%比2%，P-c = 0.012）。此外，由于IL-12Bpro和GSTP1的多态性，患者外周血单核细胞（PBMC）比健康供者产生更高的IL-12p40。综上所述，高产IL-12p40基因型IL-12Bpro-11和GSTP1-GG的纯合性对保加利亚矿工矽肺病的发生具有最高的遗传风险。
To assess the role of IL-12Bpro and GSTP1 polymorphisms on induced interleukin (IL)-12p40 production in respect to silicosis development, we examined their distribution in 63 silicosis patients and 165 healthy donors. Decreased frequencies of IL-12Bpro-2 allele (42% vs 62.5%, P = 0.0042) and genotype 22 (19% vs 40%, P = 0.02) in patients compared with exposed healthy donors suggested their protective role in silicosis susceptibility. The GSTP1 A/G polymorphism was also associated with silicosis susceptibility. The allele G and genotype GG were overrepresented among patients than among healthy men (36% vs 23%, P = 0.013; 14% vs 2%, P-c = 0.012). Also, patients' peripheral blood mononuclear cell (PBMC) produced higher IL-12p40 than healthy donors' depending on both IL-12Bpro and GSTP1 polymorphisms. In conclusion, homozygosity of high producer IL-12p40 genotype IL-12Bpro-11 and GSTP1-GG had the highest genetic risk of silicosis development in Bulgarian miners.