Biomechanical properties of ascending aorta and pulmonary trunk in pigs and humans
Biomechanical properties of ascending aorta and pulmonary trunk in pigs and humans
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DOI：
10.1111/j.1399-3089.2008.00498.x
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发表时间：
2008-11-01
影响因子：
3.9
通讯作者：
Zeng, Yan-Jun
中科院分区：
文献类型：
--
作者：
Li, Wen-Chun;Yu, Ming-Hua;Zeng, Yan-Jun
本研究旨在获得健康人和不同月龄猪的升主动脉和肺动脉干的生物力学特性，为猪-人异种心脏移植中血管再通提供必要的生物力学实验依据。（男4，女2）和42头1-7月龄中国湖北白色猪进行了生物力学试验。对血管施加周期性的永久加载和卸载，获得重复的力-变形数据。由实验数据曲线得到血管的弹性特性，猪升主动脉和肺动脉干的生物力学材料常数不随年龄的增加而增加（F = 14.569，P = 0.126）。1-7月龄人与猪的生物力学材料常数基本相似（F = 12.264，P = 0.225）。7月龄弹性模量最大（F = 27.425，P = 0.032）。不同月龄的人与猪相应血管的弹性模量无显著性差异（F = 17.328，P = 0.215），提示人与猪升主动脉和肺动脉干的弹性性质无显著性差异。从生物力学的角度来看，猪-人异种心脏移植过程中吻合相应升主动脉和肺动脉干是可行的。
This study aims to obtain the biomechanical properties of ascending aorta and pulmonary trunk between healthy humans and pigs of different months, so as to provide necessary biomechanical experimental basis for anastomosing blood vessel in pig-to-human heart xenotransplantation.Ascending aorta and pulmonary trunks of the six deceased donors (male 4, female 2) and 42 Chinese Hubei white pigs aged 1-7 months were performed biomechanical test. The blood vessel was given periodic permanent loading and unloading, and repeated force-deformation data were obtained. The elastic properties of the blood vessels were obtained by curve from experimental data.The biomechanical material constant of ascending aorta and pulmonary trunk of pigs did not increase with the increase of age (F = 14.569, P = 0.126). The biomechanical material constant of humans was basically similar to that of pigs aged 1-7 months (F = 12.264, P = 0.225). The elastic modulus was the biggest in pigs aged 7 months in comparison with that in other ages (F = 27.425, P = 0.032). There was no significant difference of elastic modulus of corresponding blood vessel between humans and pigs of different months (F = 17.328, P = 0.215).Our present study suggests that there was no significant difference of elastic properties of ascending aorta and pulmonary trunks between humans and pigs. From biomechanical aspects, anastomosis of corresponding ascending aorta and pulmonary trunks in the process of pig-to-human heart xenotransplantation may be feasible.