Propensity score methods for confounding control in nonexperimental research.
Propensity score methods for confounding control in nonexperimental research.
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DOI：
10.1161/circoutcomes.113.000359
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发表时间：
2013-09-01
期刊：
影响因子：
--
通讯作者：
Stürmer T
中科院分区：
文献类型：
--
作者：
Brookhart MA;Wyss R;Layton JB;Stürmer T
背景非实验性研究越来越多地用于调查医疗产品在日常护理中使用的安全性和有效性。此类研究的主要挑战之一是暴露于感兴趣的干预措施的患者与所选对照组之间的预后存在混杂、系统性差异。在存在未控制的混杂因素的情况下，观察到的组间结局风险的任何差异不能仅归因于暴露对结局的因果影响。
BackgroundNonexperimental studies are increasingly used to investigate the safety and effectiveness of medical products as they are used in routine care. One of the primary challenges of such studies is confounding, systematic differences in prognosis between patients exposed to an intervention of interest and the selected comparator group. In the presence of uncontrolled confounding, any observed difference in outcome risk between the groups cannot be attributed solely to a causal effect of the exposure on the outcome.