Interaction of irritability and anxiety on emotional responding and emotion regulation: a functional MRI study.
Interaction of irritability and anxiety on emotional responding and emotion regulation: a functional MRI study.
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DOI：
10.1017/s0033291720001397
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发表时间：
2021-12
影响因子：
6.9
通讯作者：
Blair RJR
中科院分区：
文献类型：
--
作者：
Crum KI;Hwang S;Blair KS;Aloi JM;Meffert H;White SF;Tyler PM;Leibenluft E;Pope K;Blair RJR
易怒和焦虑经常同时发生在儿科人群中。分别研究这些症状的神经相关性的研究已经确定了类似的神经系统的参与-特别是那些涉及情绪处理的神经系统。易怒和焦虑都可以被认为是负效价的情绪状态，可能与情绪失调有关。然而，以前的工作并没有检查的神经反应在执行情绪调节任务的功能之间的相互作用，同时烦躁和焦虑。这项fMRI研究涉及155名参与者（90名具有显著的精神病理学，92名男性），他们执行了情感Stroop任务，旨在根据任务要求进行情绪调节。情感反应指数（ARI）被用来索引易怒和儿童焦虑相关的情绪障碍筛查（SCARED）被用来索引焦虑。在视觉试验中，易怒而非焦虑的水平与右前额叶喙内侧皮层和左前扣带皮层对视觉图像的反应呈正相关。腹侧前扣带皮层的第二个区域表现出条件-情绪-ARI-SCARED评分的相互作用。具体而言，焦虑水平显着相关的差异BOLD反应负相对于中立的看法试验，但只有在存在相对较高的易怒。非典型的维持情绪刺激的吻内侧前额叶皮层可能会加剧青少年所面临的困难与易怒。此外，焦虑的增加加上明显的易怒可能会破坏一种基于情绪冲突的自动情绪调节形式，这种形式特别与腹侧前扣带皮层有关。
Irritability and anxiety frequently co-occur in pediatric populations. Studies separately looking at the neural correlates of these symptoms have identified engagement of similar neural systems – particularly those implicated in emotional processing. Both irritability and anxiety can be considered negative valence emotional states that might relate to emotion dysregulation. However, previous work has not examined the neural responding during the performance of an emotion regulation task as a function of interaction between irritability and anxiety simultaneously. This fMRI study involved 155 participants (90 with significant psychopathologies and 92 male) who performed the Affective Stroop Task, designed to engage emotion regulation as a function of task demands. The Affective Reactivity Index (ARI) was used to index irritability and the Screen for Child Anxiety Related Emotional Disorders (SCARED) was used to index anxiety. Levels of irritability, but not anxiety, was positively correlated with responses to visual images within the right rostro-medial prefrontal cortex and left anterior cingulate cortex during view trials. The second region of ventral anterior cingulate cortex showed a condition-by-emotion-by-ARI score-by-SCARED score interaction. Specifically, anxiety level was significantly correlated with a decreased differential BOLD response to negative relative to neutral view trials but only in the presence of relatively high irritability. Atypical maintenance of emotional stimuli within the rostro-medial prefrontal cortex may exacerbate the difficulties faced by adolescents with irritability. Moreover, increased anxiety combined with significant irritability may disrupt an automatic emotional conflict-based form of emotion regulation that is particularly associated with the ventral anterior cingulate cortex.