Two different putative genetic animal models of childhood depression
Two different putative genetic animal models of childhood depression
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DOI：
10.1016/j.biopsych.2005.05.039
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发表时间：
2006-01-01
影响因子：
10.6
通讯作者：
Weller, A
中科院分区：
文献类型：
--
作者：
Malkesman, O;Braw, Y;Weller, A
背景资料：在试图模拟儿童抑郁症，我们研究了是否现有的遗传动物模型的抑郁症在成年大鼠也是有效的青春期前rates.Methods：两种不同的“抑郁”大鼠行进行了研究：弗林德斯敏感线（FSL）和他们的控制，Sprague-Dawley（SD）和Wistar京都（WKY）线和他们的控制，Wistar。我们假设，男性青春期前FSI，WKY大鼠将显示增加游泳测试不动和不同的模式的社会发挥和基础血浆水平的皮质酮和促肾上腺皮质激素（ACTH）与对照rates.Results相比：青春期前FSL和WKY大鼠表现出显着较长的时间不动比对照组大鼠在游泳测试。与SD对照组大鼠相比，FSL组大鼠表现出显著的社会游戏行为水平和较低的社会游戏行为水平以及较低的皮质酮和ACTH水平，而WKY组大鼠表现出显著的社会游戏行为水平和较高的血浆皮质酮和ACTH水平。结果可能表明，青春期前FSL和WKY大鼠都是假定的儿童期抑郁症的遗传动物模型，表现出不同的模式和症状的儿童期抑郁症。
Background: In an attempt to model childhood depression, we examined whether existing genetic animal models of depression in adult rats are also valid in prepubertal rats.Methods: Two different "depressed" rat lines were studied: the Flinders Sensitive Line (FSL) and their controls, Sprague-Dawley (SD); and the Wistar Kyoto (WKY) line and their controls, Wistar. We hypothesized that male prepubertal FSI, and WKY rats would show increased swim test immobility and different patterns of social play and of basal plasma levels of corticosterone and adrenocorticotropic hormone (ACTH) compared with control rats.Results: Prepubertal FSL and WKY rats exhibited significantly longer duration of immobility than control rats in the swim test. The FSL rats demonstrated significantly higher levels of social play behaviors and lower levels of social play behaviors and lower levels of corticosterone and ACTH compared with SD control rats, whereas WKY rats demonstrated significantly lower levels of social play behaviours and higher plasma levels of corticosterone and ACTH compared with Wistar control rats.Conclusions: The results might suggest that prepubertal FSL and WKY rats are both putative genetic animal models of childhood depression, exhibiting separate patterns and symptoms of childhood depression.