The Saitohin 'Q7R' polymorphism and tau haplotype in multi-ethnic Alzheimer disease and Parkinson's disease cohorts
The Saitohin 'Q7R' polymorphism and tau haplotype in multi-ethnic Alzheimer disease and Parkinson's disease cohorts
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DOI：
10.1016/s0304-3940(03)00635-9
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发表时间：
2003-08-14
影响因子：
2.5
通讯作者：
Marder, K
中科院分区：
文献类型：
--
作者：
Clark, LN;Levy, G;Marder, K
在一个多民族队列中，我们分析了200例迟发性阿尔茨海默病（LOAD）、60例帕金森病合并痴呆（PDD）、84例无痴呆帕金森病和458例对照的Saitohin （STH）基因Q7R多态性。我们发现，与对照组相比，LOAD或PD病例的基因型或等位基因频率没有显著差异。病例和对照组的STH基因型频率存在种族差异，差异有统计学意义（病例n = 344, P < 0.03；对照组n = 458, P < 0.001）。我们还观察到，与没有痴呆的PD患者（61.7%）和对照组（56.6%）相比，具有STH 'QQ' （Tau H1/H1）基因型的非西班牙裔白人PDD患者（76%）有增加的趋势；然而，这种差异没有统计学意义（PDD vs.对照组OR 2.1; 95% CI: 0.8-5.8, P = 0.2）。(C) 2003爱思唯尔科学爱尔兰有限公司版权所有。
In a multi-ethnic cohort we analyzed the Saitohin (STH) gene 'Q7R' polymorphism in 200 late-onset Alzheimer's disease cases (LOAD), 60 Parkinson's disease cases with dementia (PDD), 84 Parkinson's disease cases without dementia and 458 controls. We found no significant differences in genotype or allele frequencies when LOAD or PD cases were compared to controls. Ethnic differences in STH genotype frequencies for cases and controls were observed and these were statistically significant (cases n = 344, P < 0.03; controls n = 458, P < 0.001). We also observed a trend in non-Hispanic white PDD cases with the STH 'QQ' (Tau H1/H1) genotype increased (76%) compared to PD cases without dementia (61.7%) and controls (56.6%); however, this difference was not statistically significant (PDD vs. controls OR 2.1; 95% CI: 0.8-5.8, P = 0.2). (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.