A single nucleotide polymorphism in the extracellular domain of TRAIL receptor DR4 at nucleotide 626 in gastric cancer patients in Japan.
A single nucleotide polymorphism in the extracellular domain of TRAIL receptor DR4 at nucleotide 626 in gastric cancer patients in Japan.
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DOI：
10.3892/or.14.2.465
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发表时间：
2005-08
期刊：
影响因子：
4.2
通讯作者：
K. Kuraoka;Shunji Matsumura;Y. Sanada;K. Nakachi;K. Imai;H. Eguchi;K. Matsusaki;N. Oue;H. Nakayama;W. Yasui
中科院分区：
文献类型：
--
作者：
K. Kuraoka;Shunji Matsumura;Y. Sanada;K. Nakachi;K. Imai;H. Eguchi;K. Matsusaki;N. Oue;H. Nakayama;W. Yasui
死亡受体4（DR 4）是肿瘤坏死因子相关凋亡诱导配体受体基因的成员。据报道，细胞外结构域中的单核苷酸多态性（Thr或Arg，C或G）与肺癌，头颈癌和膀胱癌的风险相关。在这项研究中，我们研究了DR 4多态性与胃癌之间的关联。Thr/Thr、Thr/Arg和Arg/Arg基因型分别在274例胃癌患者中检出250例（91.2%）、23例（8.4%）和1例（0.4%），在344例对照组中检出317例（92.2%）、21例（6.1%）和6例（1.7%）。与Thr/Thr基因型相比，Thr/Arg或Arg/Arg基因型的OR值为1.13（95%CI，0.63-2.00），提示DR 4基因多态性并不改变胃癌的危险性。在胃癌患者中，DR 4基因型与胃癌的临床病理特征（浸润深度、淋巴结转移、远处转移、分期和分化程度）无相关性;免疫组化结果显示，DR 4基因在胃癌中持续表达，而在非肿瘤性胃上皮中不表达。结论：DR 4胞外区Thr → Arg单核苷酸多态性与胃癌的发生、发展无关。
Death receptor 4 (DR4) is a member of the tumor necrosis factor-related apoptosis-inducing ligand receptor genes. A single nucleotide polymorphism (Thr or Arg, C or G) in the extracellular domain was reported to be associated with a risk of lung cancer, head and neck cancer, and bladder cancer. In this study, we examined the association between the DR4 polymorphism and gastric cancer. The Thr/Thr, Thr/Arg and Arg/Arg genotypes were found in 250 (91.2%), 23 (8.4%) and 1 (0.4%) of 274 gastric cancer patients and in 317 (92.2%), 21 (6.1%) and 6 (1.7%) of 344 control subjects, respectively. The OR of Thr/Arg or Arg/Arg genotype did not reveal a significantly enhanced risk of 1.13 (95% CI, 0.63-2.00) compared to Thr/Thr genotype, suggesting that the DR4 polymorphism did not modify the risk of gastric cancer. In patients, no association between the genotype and clinicopathological characteristics (depth of invasion, lymph node metastasis, distant metastasis, stage and grade of differentiation) of gastric carcinoma was found. DR4 was constantly expressed in gastric carcinoma, but not in non-neoplastic gastric epithelium in immunohistochemistry. In conclusion, a Thr to Arg single nucleotide polymorphism in the extracellular domain of DR4 could not be associated with the development and progression of gastric cancer.