Controlled isoflurane anesthesia exposure is required for reliable behavioral testing in murine surgical models
Controlled isoflurane anesthesia exposure is required for reliable behavioral testing in murine surgical models
复制标题
在小鼠手术模型中进行可靠的行为测试需要受控的异氟醚麻醉暴露
DOI：
10.1016/j.jphs.2019.03.007
复制
发表时间：
2019
期刊：
影响因子：
3.5
通讯作者：
Mogi M
中科院分区：
文献类型：
--
作者：
Toyama K;Spin JM;Abe Y;Suzuki Y;Deng AC;Wagenhauser MU;Yoshino T;Mulorz J;Liu S;Tsao PS;Mogi M
We investigated the effects of variations in anesthesia exposure time prior to conducting anxiety response behavioral testing in sham controls from an experimental murine model. The staying time in the center area of the Open Field test in the “long exposure” group was significantly decreased compared to that of the “short exposure” group. Significant correlation was found between anesthesia time and the duration of staying time in the center area. We conclude that anesthesia time may have a significant impact on behavioral anxiety testing in this context, and advise careful control of this parameter in protocol optimization in related surgical animal models.
