Histamine and Microglia
Histamine and Microglia
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组胺和小胶质细胞
DOI：
10.1007/7854_2022_322
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Yoshikawa T.
中科院分区：
文献类型：
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作者：
Iida T;Yanai K;Yoshikawa T.
小胶质细胞是中枢神经系统（CNS）中的一类神经胶质细胞，因其在神经炎症中的重要作用而备受关注。目前正在进行许多转化研究，以发现针对小胶质细胞的新药物，用于治疗各种中枢神经系统疾病，例如阿尔茨海默病、帕金森病 (PD) 和抑郁症。最近的研究表明，大脑组胺是调节多种大脑功能所必需的神经递质，它控制神经胶质细胞和神经元。使用原代小胶质细胞和小胶质细胞系的体外研究报道，组胺受体在小胶质细胞中表达并控制小胶质细胞的功能，包括趋化性、迁移、细胞因子分泌和自噬。体内研究表明，组胺相关试剂可以改善人类疾病动物模型的异常症状，例如肌萎缩侧索硬化症（ALS）、PD和脑缺血。几项人类研究揭示了 ALS 和 PD 中组胺受体水平的变化，强调了中枢神经系统组胺系统（包括组胺依赖性小胶质细胞调节）作为这些疾病的治疗靶点的重要性。在这篇综述文章中，我们总结了以小胶质细胞功能为重点的组胺相关研究。
Microglia, a category of glial cells in the central nervous system (CNS), have attracted much attention because of their important role in neuroinflammation. Many translational studies are currently ongoing to discover novel drugs targeting microglia for the treatment of various CNS disorders, such as Alzheimer’s disease, Parkinson’s disease (PD), and depression. Recent studies have shown that brain histamine, a neurotransmitter essential for the regulation of diverse brain functions, controls glial cells and neurons. In vitro studies using primary microglia and microglial cell lines have reported that histamine receptors are expressed in microglia and control microglial functions, including chemotaxis, migration, cytokine secretion, and autophagy. In vivo studies have demonstrated that histamine-related reagents could ameliorate abnormal symptoms in animal models of human diseases, such as amyotrophic lateral sclerosis (ALS), PD, and brain ischemia. Several human studies have revealed alterations in histamine receptor levels in ALS and PD, emphasizing the importance of the CNS histamine system, including histamine-dependent microglial modulation, as a therapeutic target for these disorders. In this review article, we summarize histamine-related research focusing on microglial functions.