Oncogenic seRNA functional activation: a novel mechanism of tumorigenesis
Oncogenic seRNA functional activation: a novel mechanism of tumorigenesis
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致癌seRNA功能激活：肿瘤发生的新机制
DOI：
10.1186/s12943-020-01195-5
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发表时间：
2020-04
期刊：
影响因子：
--
通讯作者：
Tang F
中科院分区：
文献类型：
--
作者：
Tan Y;Li Y;Tang F
seRNA is a noncoding RNA (ncRNA) transcribed from active super-enhancer (SE), through which SE exerts biological functions and participates in various physiological and pathological processes. seRNA recruits cofactor, RNA polymerase II and mediator to constitute and stabilize chromatin loop SE and promoter region, which regulates target genes transcription. In tumorigenesis, DNA insertion, deletion, translocation, focal amplification and carcinogen factor mediate oncogenic SE generation, meanwhile, oncogenic SE transcribes into tumor-related seRNA, termed as oncogenic seRNA. Oncogenic seRNA participates in tumorigenesis through activating various signal-pathways. The recent reports showed that oncogenic seRNA implicates in a widespread range of cytopathological processes in cancer progression including cell proliferation, apoptosis, autophagy, epithelial-mesenchymal transition, extracellular matrix stiffness and angiogenesis. In this article, we comprehensively summarized seRNA’s characteristics and functions, and emphatically introduced inducible formation of oncogenic seRNA and its functional mechanisms. Lastly, some research strategies on oncogenic seRNA were introduced, and the perspectives on cancer therapy that targets oncogenic seRNA were also discussed.
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de la Chapelle A
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DOI：
10.1089/scd.2019.0014
发表时间：
2019
期刊：
Stem Cells Dev
影响因子：
--
作者：
Zhiyao Yuan;Yifeng Bian;Xiaojie Ma;Zichun Tang;Ning Chen;Ming Shen
通讯作者：
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