Upper bounds on FST in terms of the frequency of the most frequent allele and total homozygosity: The case of a specified number of alleles
Upper bounds on FST in terms of the frequency of the most frequent allele and total homozygosity: The case of a specified number of alleles
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DOI：
10.1016/j.tpb.2014.08.001
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发表时间：
2014-11-01
影响因子：
1.4
通讯作者：
Rosenberg, Noah A.
中科院分区：
文献类型：
--
作者：
Edge, Michael D.;Rosenberg, Noah A.
F-ST是群体间遗传分化最常用的指标之一。虽然F-ST的取值范围在0到1之间，但追溯到Wright的作者已经注意到，在许多情况下，F-ST被限制为小于1。最近，我们发现在一个等位基因数目未确定的遗传位点上，两个亚群体的F-ST由最常见等位基因的频率(M)和总体纯合性（H-T）的函数严格限定。在两个亚群的情况下，只有当最常见等位基因的频率和总纯合性为1/2时，F-ST才能等于1。在这里，我们扩展了这一工作，推导出当位点上的等位基因数为1时，两个亚种群的F-ST的严格界限。我们表明，在M和H-T的大部分允许域上，限制为1个等位基因会产生相同的F-ST上界，并且我们在窗口中推导出更严格的界限，M是[1/I， 1/（I - 1))的元素，H-T是[1/I， I/(I-2 - 1)）的元素。这些结果扩展了我们对F-ST行为与其他群体遗传统计的理解。(C) 2014爱思唯尔公司版权所有。
F-ST is one of the most frequently-used indices of genetic differentiation among groups. Though F-ST takes values between 0 and 1, authors going back to Wright have noted that under many circumstances, F-ST is constrained to be less than 1. Recently, we showed that at a genetic locus with an unspecified number of alleles, F-ST for two subpopulations is strictly bounded from above by functions of both the frequency of the most frequent allele (M) and the homozygosity of the total population (H-T). In the two-subpopulation case, F-ST can equal one only when the frequency of the most frequent allele and the total homozygosity are 1/2. Here, we extend this work by deriving strict bounds on F-ST for two subpopulations when the number of alleles at the locus is specified to be I. We show that restricting to I alleles produces the same upper bound on F-ST over much of the allowable domain for M and H-T, and we derive more restrictive bounds in the windows M is an element of[1/I, 1/(I - 1)) and H-T is an element of [1/I, I/(I-2 - 1)). These results extend our understanding of the behavior of F-ST in relation to other population-genetic statistics. (C) 2014 Elsevier Inc. All rights reserved.