Borders and Comparative Cytoarchitecture of the Perirhinal and Postrhinal Cortices in an F1 Hybrid Mouse
Borders and Comparative Cytoarchitecture of the Perirhinal and Postrhinal Cortices in an F1 Hybrid Mouse
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DOI：
10.1093/cercor/bhs038
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发表时间：
2013-02-01
期刊：
影响因子：
3.7
通讯作者：
Burwell, Rebecca D.
中科院分区：
文献类型：
--
作者：
Beaudin, Stephane A.;Singh, Teghpal;Burwell, Rebecca D.
我们研究了小鼠大脑中与后鼻裂相关的皮质区域的细胞结构和化学结构组织，在已知的大鼠这些区域的框架内。主要观察结果在第一代杂交小鼠系B6129 PF/J1中进行。选择F1杂种是因为在学习和记忆的分子和细胞基础的研究中提供了许多优势。并与亲本菌株C57 BL 6/J和129 P3/J进行了比较。小鼠脑组织进行处理的尼氏物质，髓鞘，乙酰胆碱酯酶，小清蛋白，和重金属的可视化。组织染色的重金属的Timm的方法是特别有用的边界的分配和比较分析，因为染色的模式是相似的物种和菌株。与大鼠一样，将检查区域分成2个区域，即嗅周和嗅后皮质。嗅周皮层分为35和36区，嗅后皮层分为背侧（PORd）和腹侧（PORV）亚区。除了识别嗅周皮层的边界外，我们还能够识别小鼠大脑中与大鼠嗅后皮层共享签名特征的区域。
We examined the cytoarchitectonic and chemoarchitectonic organization of the cortical regions associated with the posterior rhinal fissure in the mouse brain, within the framework of what is known about these regions in the rat. Primary observations were in a first-generation hybrid mouse line, B6129PF/J1. The F1 hybrid was chosen because of the many advantages afforded in the study of the molecular and cellular bases of learning and memory. Comparisons with the parent strains, the C57BL6/J and 129P3/J are also reported. Mouse brain tissue was processed for visualization of Nissl material, myelin, acetyl cholinesterase, parvalbumin, and heavy metals. Tissue stained for heavy metals by the Timm's method was particularly useful in the assignment of borders and in the comparative analyses because the patterns of staining were similar across species and strains. As in the rat, the areas examined were parcellated into 2 regions, the perirhinal and the postrhinal cortices. The perirhinal cortex was divided into areas 35 and 36, and the postrhinal cortex was divided into dorsal (PORd) and ventral (PORv) subregions. In addition to identifying the borders of the perirhinal cortex, we were able to identify a region in the mouse brain that shares signature features with the rat postrhinal cortex.