Refractive Power and Biometric Properties of the Nonhuman Primate Isolated Crystalline Lens
Refractive Power and Biometric Properties of the Nonhuman Primate Isolated Crystalline Lens
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DOI：
10.1167/iovs.09-3905
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发表时间：
2010-04-01
影响因子：
4.4
通讯作者：
Parel, Jean-Marie
中科院分区：
文献类型：
--
作者：
Borja, David;Manns, Fabrice;Parel, Jean-Marie
目的.研究灵长类离体晶状体的形状、屈光力和折射率的年龄依赖性。对食蟹猴（食蟹猴：n = 120;年龄，2.7-14.3岁）、恒河猴（n = 61;年龄，0.7-13.3岁）和hamadryas狒狒（狒狒：n = 16;年龄，1.7-27.3岁）的离体晶状体进行测量。使用光学比较仪测量透镜厚度、直径和表面曲率。使用基于Scheiner原理的定制光学系统测量透镜屈光力。利用光线追迹软件计算了梯度、表面和等效折射率的折射率贡献。的光学和生物特征参数的年龄依赖性进行了评估。在测量的年龄范围内，孤立的透镜厚度降低（狒狒：-0.04，食蟹猴：-0.05，恒河猴：-0.06 mm/y），赤道直径增加（狒狒和恒河猴的赤道直径增加，食蟹猴的赤道直径增加：0.07 mm/y）。孤立的透镜表面变平，并且表面的相应屈光力随年龄而降低（-0.33、-0.48和-0.68 D/y）。离体透镜等效折射率降低（仅狒狒显著，-0.001 D/y），因此总离体透镜屈光力随年龄降低（狒狒：-1.26，食蟹猴：-0.97，恒河猴：-1.76 D/y）。非人灵长类动物晶状体的光学和生物特征、生长和老化的年龄依赖性趋势与老花眼前人类透镜的趋势相似。随着透镜老化，梯度折射率的折射贡献的降低导致最大调节透镜折射能力的快速年龄依赖性降低。（Invest Ophthalmol维斯科学。2010; 51：2118-2125）DOI：10.1167/iovs.09-3905
PURPOSE. To characterize the age dependence of shape, refractive power, and refractive index of isolated lenses from nonhuman primates.METHODS. Measurements were performed on ex vivo lenses from cynomolgus monkeys (cyno: n = 120; age, 2.7-14.3 years), rhesus monkeys (n = 61; age, 0.7-13.3 years), and hamadryas baboons (baboon: n = 16; age, 1.7-27.3 years). Lens thickness, diameter, and surface curvatures were measured with an optical comparator. Lens refractive power was measured with a custom optical system based on the Scheiner principle. The refractive contributions of the gradient, the surfaces, and the equivalent refractive index were calculated with optical ray-tracing software. The age dependence of the optical and biometric parameters was assessed.RESULTS. Over the measured age range isolated lens thickness decreased (baboon: -0.04, cyno: -0.05, and rhesus: -0.06 mm/y) and equatorial diameter increased (logarithmically for the baboon and rhesus, and linearly for cyno: 0.07 mm/y). The isolated lens surfaces flattened and the corresponding refractive power from the surfaces decreased with age (-0.33, -0.48, and -0.68 D/y). The isolated lens equivalent refractive index decreased (only significant for the baboon, -0.001 D/y), and as a result the total isolated lens refractive power decreased with age (baboon: -1.26, cyno: -0.97, and rhesus: -1.76 D/y).CONCLUSIONS. The age-dependent trends in the optical and biometric properties, growth, and aging, of nonhuman primate lenses are similar to those of the pre-presbyopic human lens. As the lens ages, the decrease in refractive contributions from the gradient refractive index causes a rapid age-dependent decrease in maximally accommodated lens refractive power. (Invest Ophthalmol Vis Sci. 2010; 51: 2118-2125) DOI:10.1167/iovs.09-3905