Prevalence of asthma, allergic rhinoconjunctivitis and allergic sensitization in Mongolia
Prevalence of asthma, allergic rhinoconjunctivitis and allergic sensitization in Mongolia
复制标题
DOI：
10.1111/j.1398-9995.2005.00877.x
复制
发表时间：
2005-11-01
期刊：
影响因子：
12.4
通讯作者：
Terho, EO
中科院分区：
文献类型：
--
作者：
Viinanen, A;Munhbayarlah, S;Terho, EO
背景：在蒙古等从农业社会向工业社会转型的国家进行的研究允许评估环境变化对特应性疾病的影响。方法：在筛查研究中，获得了9453名10-60岁的受试者的问卷数据。在临床研究中，对869名受试者(参与率为50.0%)进行了抽样调查。采用问卷式访谈、临床检查、皮肤点刺试验、肺活量测定和支气管扩张试验或乙酰甲胆碱激发试验确定临床诊断。结果：蒙古族农村居民哮喘、过敏性鼻结膜炎和过敏性疾病患病率分别为1.1%(0.3~2.0%)、9.3%(4.0~14.6%)和13.6%(7.4~19.9%)，95%可信区间分别为2.4%(1.4~3.5%)和2.4%(1.4%~3.5%)。农村分别为12.9%(8.2-17.7%)和25.3%(17.1-33.6%)，乌兰巴托市分别为2.1%(1.3-3.0%)、18.4%(13.3-23.4%)和31.0%(24.5-37.5%)。变态反应性鼻结膜炎(P=0.02)和过敏性变态反应(P=0.003)的患病率随着城市化程度的增加而显著增加。结论：蒙古国农村特应性疾病的患病率较低，并随着城市化程度的提高而增加，提示农村生活环境对特应性疾病具有保护作用。
Background: Studies in countries, such as Mongolia, which are in transition from farming to industrial society permit evaluation of the impact of environmental change on atopic diseases.Methods: In the screening study, questionnaire data were obtained from 9453 subjects aged 10-60 years. In the clinical study, a subsample of 869 subjects (participation rate 50.0%) was examined. A questionnaire-based interview, clinical examination, skin prick tests, spirometry and bronchodilation test or methacholine challenge test were used to define the clinical diagnoses. The prevalences of atopic diseases were evaluated at the population level using two-phase data and sampling weights.Results: The prevalences of asthma, allergic rhinoconjunctivitis and allergic sensitization with 95% confidence intervals were 1.1% (0.3-2.0%), 9.3% (4.0-14.6%) and 13.6% (7.4-19.9%) in Mongolian villages, 2.4% (1.4-3.5%), 12.9% (8.2-17.7%) and 25.3% (17.1-33.6%) in rural towns and 2.1% (1.3-3.0%), 18.4% (13.3-23.4%) and 31.0% (24.5-37.5%) in Ulaanbaatar city, respectively. The prevalence of allergic rhinoconjunctivitis (P = 0.02) and allergic sensitization (P = 0.003) increased significantly with increasing urbanization.Conclusions: The prevalences of atopic diseases were low in rural Mongolia and increased with increasing urbanization suggesting that rural living environment protects against atopy.