Activity of a traditional South African epilepsy remedy in the GABA-benzodiazepine receptor assay.
Activity of a traditional South African epilepsy remedy in the GABA-benzodiazepine receptor assay.
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DOI：
10.1016/j.jep.2004.10.005
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发表时间：
2005-01
影响因子：
5.4
通讯作者：
A. Jäger;S. P. Mohoto;F. V. van Heerden;A. Viljoen
中科院分区：
文献类型：
--
作者：
A. Jäger;S. P. Mohoto;F. V. van Heerden;A. Viljoen
采用gabaa -苯二氮卓受体结合试验，对古代北索索人治疗癫痫的药物Sehlare sa Seebana中的六种植物（Acrotome inflata、Aptosimum indium、suaveolens、Barleria bolusii、Commiphora marlothii和Sesamum triphyllum）的水提液和乙醇提取物进行了测试。杏叶、芦笋的水提液和乙醇提液以及马氏金缕草的水提液均表现出良好的剂量依赖性活性。同时提取的六种植物的乙醇提取物比水提取物更有活性。结果表明，植物混合物没有增效作用。
Aqueous and ethanol extracts of six plants, Acrotome inflata, Aptosimum indivisum, Asparagus suaveolens, Barleria bolusii, Commiphora marlothii and Sesamum triphyllum, which constitute an ancient Northern Sotho remedy for epilepsy, Sehlare sa Seebana, was tested in the GABAA-benzodiazepine receptor binding assay. Both aqueous and ethanol extracts of Aptosimum indivisum and Asparagus suaveolens and the aqueous extract of Commiphora marlothii showed good dose-dependent activity. The ethanol extract of all six plants extracted together was more active that the aqueous extract. The results did not suggest a synergistic effect of the plant mixture.