Correlation of Clinical Outcomes with β-Glucan Levels in Patients with Invasive Candidiasis
Correlation of Clinical Outcomes with β-Glucan Levels in Patients with Invasive Candidiasis
复制标题
侵袭性念珠菌病患者临床结果与 β-葡聚糖水平的相关性
DOI：
10.1128/jcm.00773-12
复制
发表时间：
2012
影响因子：
9.4
通讯作者：
L. Ostrosky
中科院分区：
文献类型：
--
作者：
C. Sims;Siraya Jaijakul;John F. Mohr;J. Rodríguez;M. Finkelman;L. Ostrosky
侵袭性念珠菌病(IC)患者β-葡聚糖(BG)水平与临床预后的相关性尚不清楚。对确诊为IC的患者进行前瞻性跟踪，从诊断到预后，每周两次血清BG采样。对每个患者的血糖与临床结果的相关性进行评估。在治疗成功的患者中，血糖水平往往会下降，而治疗失败的患者会增加。血糖水平可作为IC预后评估的替代指标。
ABSTRACT The correlation of β-glucan (BG) levels with clinical outcomes in invasive candidiasis (IC) remains unknown. Patients with proven IC were followed prospectively from diagnosis to outcome with twice-weekly serum BG sampling. Correlation of BG with clinical outcome was assessed in each patient. BG levels tend to decrease in successfully treated patients and increase in treatment failures. BG levels may be useful as surrogates for outcome evaluation of IC.