Molecular Characteristics and Expression Profile of the Rheb Gene in Rongchang Piglets ( Sus scrofa )
Molecular Characteristics and Expression Profile of the Rheb Gene in Rongchang Piglets ( Sus scrofa )
复制标题
荣昌仔猪Rheb基因的分子特征及表达谱
DOI：
10.18805/ijar.5563
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发表时间：
2015
影响因子：
0.5
通讯作者：
Fuyuan Zuo
中科院分区：
文献类型：
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作者：
L. Gan;H. Mei;Binyu Yang;Fuyuan Zuo
为了深入了解荣昌仔猪Rheb信号通路的遗传功能，本研究鉴定了荣昌仔猪Rheb基因的完整编码序列，表明其完整编码区序列长555bp，编码184个氨基酸，几乎包含Rheb蛋白家族的所有保守蛋白结构域。推测荣昌猪与绵羊、牛或山羊的氨基酸序列同一性分别为100%、99%和98%。空间转录谱分析表明，Rheb 基因在唾液腺和大脑中均以非常高的水平表达，特别是在大脑的下丘脑和腹侧海马 (VH) 区域。发育表达谱分析显示，这两个品种仔猪的大脑亚区和唾液腺的表达模式不同，尽管荣昌仔猪和大白仔猪的mRNA水平不同，但表达模式相似。
To give some insights into the genetic functions of Rheb signaling pathway in Rongchang piglets, this study reported the identification of complete coding sequence of the Rheb gene in Rongchang piglets and indicated that the complete coding region sequence is 555bp in length and encodes 184 amino acids, containing nearly all the conserved protein domains in the Rheb protein family. The deduced amino acid sequence identity between the Rongchang pig and sheep, cattle, or goat is 100%, 99% and 98%, respectively. Spatial transcriptional profile analysis indicated that the Rheb gene is expressed at remarkably high levels in both salivary gland and brain, especially in hypothalamus and ventral hippocampus (VH) regions of brain. Developmental expression profile analysis revealed the expression pattern is different between brain sub-regions and salivary gland of these two breeds of piglets, with the similar expression pattern despite various mRNA levels between Rongchang and Large White piglets.
影响因子：
--
作者：
J. Urano;Chad A. Ellis;Geoff Clark;Fuyuhiko Tamanoi
通讯作者：
J. Urano;Chad A. Ellis;Geoff Clark;Fuyuhiko Tamanoi
Rheb1 是产后大脑发育中 mTORC1 和髓鞘形成所必需的。
影响因子：
11.8
作者：
Zou, Jia;Zhou, Liang;Du, Xiao-Xia;Ji, Yifei;Xu, Jia;Tian, Junlong;Jiang, Wanxiang;Zou, Yi;Yu, Shouyang;Gan, Lingxue;Luo, Maowen;Yang, Qiaona;Cui, Yiyuan;Yang, Wanchun;Xia, Xiaoqiang;Chen, Mina;Zhao, Xia;Shen, Ying;Chen, Po Yu;Worley, Paul F.;Xiao, Bo
通讯作者：
Xiao, Bo