Correlation of frontal atrophy with behavioral changes in amyotrophic lateral sclerosis
Correlation of frontal atrophy with behavioral changes in amyotrophic lateral sclerosis
复制标题
肌萎缩侧索硬化症额叶萎缩与行为变化的相关性
DOI：
10.1111/ncn3.12046
复制
发表时间：
2016
影响因子：
0.4
通讯作者：
Kinya Yamazaki and Kouichi Mizoguchi
中科院分区：
文献类型：
--
作者：
Tatsuhiro Terada;Tomokazu Obi;Jun Miyata;Manabu Kubota;Miho Yoshizumi;Toshiya Murai;Kinya Yamazaki and Kouichi Mizoguchi
背景最近的研究将肌萎缩侧索硬化症的认知障碍与额颞叶病理联系起来。目的我们检查了早期肌萎缩侧索硬化症的行为改变与区域灰质体积之间可能的关联，并评估了体积变化是否独立于身体损伤。方法共17例肌萎缩侧索硬化症患者，其简易精神状态检查评分≥24分，日常生活无需协助，呼吸检查正常（呼吸功能测试和呼吸功能检查）。动脉血气分析物），并对 11 名年龄匹配的对照组进行了结构磁共振成像。通过家庭评级额叶系统行为量表评估行为变化。我们应用基于体素的形态测量学来研究额叶系统行为量表与灰质体积之间的相关性，并评估了体积与肌萎缩侧索硬化症功能评定量表和呼吸测试的相关性。结果当前额叶系统行为量表评分显着高于评估发病前状态的回顾性评分，尤其是冷漠状态。肌萎缩侧索硬化症患者右额中回和左内侧额回体积与额叶系统行为量表呈负相关，而与肌萎缩侧索硬化症功能评定量表和呼吸测试无相关性。右侧额叶簇的体积显着小于对照组，但左侧内侧额叶簇的体积明显小于对照组。结论额叶内的区域萎缩与早期肌萎缩侧索硬化症的行为功能障碍相关，这种关联与身体因素无关。
BackgroundRecent studies have linked cognitive impairment in amyotrophic lateral sclerosis to frontotemporal pathology.AimWe examined possible associations between behavior changes and regional gray matter volume in early amyotrophic lateral sclerosis, and assessed whether the volume changes were independent of physical impairments.MethodsA total of 17 amyotrophic lateral sclerosis patients with Mini‐Mental State Examination score ≥ 24, no need for assistance in daily life and normal respiratory tests (respiratory function test and arterial blood gas analytes), and 11 age‐matched controls underwent structural magnetic resonance imaging. Behavioral changes were assessed with family‐rating Frontal Systems Behavior Scale. We applied voxel‐based morphometry to investigate the correlation between the Frontal Systems Behavior Scale and gray matter volume, and assessed the correlation of volume with amyotrophic lateral sclerosis Functional Rating Scale and respiratory tests.ResultsCurrent Frontal Systems Behavior Scale scores were significantly higher than retrospective scores assessing the status before onset, most notably in apathy. The volumes of right middle and left medial frontal gyri in amyotrophic lateral sclerosis were negatively correlated with the Frontal Systems Behavior Scale, whereas they were not correlated with amyotrophic lateral sclerosis Functional Rating Scale and respiratory tests. The volume of the right frontal cluster, but not the left medial frontal cluster, was significantly smaller than that of controls.ConclusionsRegional atrophy within the frontal lobe was associated with behavioral dysfunction in early amyotrophic lateral sclerosis, this association was independent of physical factors.