The HTR1B 861G>C receptor polymorphism among patients suffering from alcoholism, major depression, anxiety disorders and narcolepsy
The HTR1B 861G>C receptor polymorphism among patients suffering from alcoholism, major depression, anxiety disorders and narcolepsy
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DOI：
10.1016/s0165-1781(00)00215-8
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发表时间：
2000-12-04
影响因子：
11.3
通讯作者：
Dahmen, N
中科院分区：
文献类型：
--
作者：
Fehr, C;Grintschuk, N;Dahmen, N
HTR1B受体基因与芬兰人和美国印第安人部落中的反社会酒精中毒有关[Lappalainen等人，Arch.精神病学杂志，55(1998)989]。采用候选基因方法，对209例酒精中毒患者、108例抑郁症患者、32例惊恐障碍患者、50例广泛性焦虑症患者、58例发作性睡病患者和74名健康志愿者的HTR1B 861G>；C基因多态性进行了基因分型。酒精依赖组HTR1B 861G等位基因频率明显高于对照组(x~(2)=4.02，D.F.=2，P=0.04)。然而，正如Lappalainen等人最初报道的那样，这种关联是由于相反等位基因(HTR1B 861G)的较高频率导致的。(1998年)。尽管我们研究中的关联可能是由于I型错误，但两个人群中较高程度的HTR1B等位基因共享也可能证明在人类6号染色体上HTR1B基因附近存在另一个与酒精中毒相关的基因。(C)2000 Elsevier Science爱尔兰有限公司。保留所有权利。
The HTR1B receptor gene has been linked to antisocial alcoholism in a Finnish population and an American Indian tribe [Lappalainen et al., Arch. Gen. Psychiatry, 55 (1998) 989]. Using a candidate gene approach, we genotyped 209 patients with alcoholism, 108 patients with major depression, 32 patients with panic disorder, 50 patients with generalized anxiety disorder, 58 patients with narcolepsy and 74 healthy volunteers for the HTR1B 861G > C polymorphism. There was a higher frequency of the HTR1B 861G alleles among the alcohol-dependent patients as compared to the control subjects (chi (2) = 4.02, d.f. = 2, P = 0.04). However, the association resulted from higher frequencies of the opposite alleles (HTR1B 861G), as originally reported by Lappalainen et al. (1998). Although the association in our study might be due to a type I error, the higher degree of HTR1B allele sharing within both populations could also argue for another alcoholism-relevant gene within the proximity of the HTR1B gene on human chromosome 6. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.