Brain hydrogen sulfide is severely decreased in Alzheimer's disease (Retracted Article)
Brain hydrogen sulfide is severely decreased in Alzheimer's disease (Retracted Article)
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DOI：
10.1016/s0006-291x(02)00422-9
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发表时间：
2002-05-24
影响因子：
3.1
通讯作者：
Kimura, H
中科院分区：
文献类型：
--
作者：
Eto, K;Asada, T;Kimura, H
虽然硫化氢（H2S）通常被认为是一种有毒气体，但它是由半胱氨酸通过胱硫醚β-合酶（CBS）在大脑中内源性产生的。H2S也作为神经调节剂发挥作用，L是平滑肌松弛剂。在这里，我们表明，HS的水平严重降低阿尔茨海默氏病（AD）患者的大脑与年龄匹配的正常人的大脑相比。除了产生H2S之外，CBS还催化另一种代谢途径，其中由底物同型半胱氨酸产生胱硫醚。以前的研究结果，表明S-腺苷-L-甲硫氨酸（SAM），CBS激活剂，是大大减少在AD脑和同型半胱氨酸积累在AD患者的血清中，得到证实。这些观察结果表明，CBS活性降低，在AD大脑和减少H2S可能涉及在AD的认知能力下降的某些方面。(C)2002 Elsevier Science（美国）。All rights reserved.
Although hydrogen sulfide (H2S) is generally thought of in terms of a poisonous gas, it is endogenously produced in the brain from cysteine by cystathionine beta-synthase (CBS). H2S functions as a neuromodulator as well Lis a smooth muscle relaxant. Here we show that the levels of HS are severely decreased in the brains of Alzheimer's disease (AD) patients compared with the brains of the age matched normal individuals. In addition to H2S production CBS also catalyzes another metabolic pathway in which cystathionine is produced from the substrate homocysteine. Previous findings, which showed that S-adenosyl-L-methionine (SAM), a CBS activator, is much reduced in AD brain and that homocysteine accumulates in the serum of AD patients, were confirmed. These observations suggest that CBS activity is reduced in AD brains and the decrease in H2S may be involved in some aspects of the cognitive decline in AD. (C) 2002 Elsevier Science (USA). All rights reserved.