Emergency ventilator for COVID-19.
Emergency ventilator for COVID-19.
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DOI：
10.1371/journal.pone.0244963
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发表时间：
2020
期刊：
影响因子：
3.7
通讯作者：
Wooldridge AR
中科院分区：
文献类型：
--
作者：
King WP;Amos J;Azer M;Baker D;Bashir R;Best C;Bethke E;Boppart SA;Bralts E;Corey RM;Dietkus R;Durack G;Elbel S;Elliott G;Fava J;Goldenfeld N;Goldstein MH;Hayes C;Herndon N;Jamison S;Johnson B;Johnson H;Johnson M;Kolaczynski J;Lee T;Maslov S;McGregor DJ;Milner D;Moller R;Mosley J;Musser A;Newberger M;Null D;O'Bryan L;Oelze M;O'Leary J;Pagano A;Philpott M;Pianfetti B;Pille A;Pizzuto L;Ricconi B;Rubessa M;Rylowicz S;Shipley C;Singer AC;Stewart B;Switzky R;Tawfick S;Wheeler M;White K;Widloski EM;Wood E;Wood C;Wooldridge AR
2019冠状病毒病疫情于二零二零年以前所未有的速度蔓延，并于数月内造成数万人死亡，令全球陷入混乱。在需要医院护理的病人人数超过可获得护理人数的地区，死亡人数急剧增加。许多COVID-19患者会出现急性呼吸窘迫综合征（ARDS），这是一种可以通过机械通气治疗的疾病。为了满足对机械呼吸机的需求，设计并测试了一种紧急呼吸机（EV），该呼吸机可以控制患者的峰值吸气压力（PIP）和呼吸频率，同时保持呼气末正压（PEEP）。本文介绍了电动汽车的快速设计，原型和测试。开发过程通过使用增材制造（AM）的快速设计迭代来实现。在最初的设计阶段，设计、AM和测试之间的迭代使工作原型在一周内完成。通过增材制造和测试总共283个具有参数变化尺寸的部件，锁定了呼吸机16个不同组件的设计。在第二阶段，AM用于生产75个功能原型，以支持工程评估和动物试验。这些器械的测试周期超过200万次。我们还开发了一个电子监控系统，并配备自动报警器，以确保安全操作，沿着培训材料和用户指南。最终的设计可以在网上免费获得。这些设计已转让给15个国家的70多个组织。该项目展示了COVID-19应急响应所需医疗设备的超快速产品设计、工程和测试的潜力。
The COVID-19 pandemic disrupted the world in 2020 by spreading at unprecedented rates and causing tens of thousands of fatalities within a few months. The number of deaths dramatically increased in regions where the number of patients in need of hospital care exceeded the availability of care. Many COVID-19 patients experience Acute Respiratory Distress Syndrome (ARDS), a condition that can be treated with mechanical ventilation. In response to the need for mechanical ventilators, designed and tested an emergency ventilator (EV) that can control a patient’s peak inspiratory pressure (PIP) and breathing rate, while keeping a positive end expiratory pressure (PEEP). This article describes the rapid design, prototyping, and testing of the EV. The development process was enabled by rapid design iterations using additive manufacturing (AM). In the initial design phase, iterations between design, AM, and testing enabled a working prototype within one week. The designs of the 16 different components of the ventilator were locked by additively manufacturing and testing a total of 283 parts having parametrically varied dimensions. In the second stage, AM was used to produce 75 functional prototypes to support engineering evaluation and animal testing. The devices were tested over more than two million cycles. We also developed an electronic monitoring system and with automatic alarm to provide for safe operation, along with training materials and user guides. The final designs are available online under a free license. The designs have been transferred to more than 70 organizations in 15 countries. This project demonstrates the potential for ultra-fast product design, engineering, and testing of medical devices needed for COVID-19 emergency response.
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影响因子：
44.1
作者：
Pastor-Satorras, Romualdo;Castellano, Claudio;Vespignani, Alessandro
通讯作者：
Vespignani, Alessandro
紧急呼吸机传感器和警报的低复杂系统和算法。
DOI：
10.1109/tbcas.2020.3020702
发表时间：
2020-10
影响因子：
5.1
作者：
Corey RM;Widloski EM;Null D;Ricconi B;Johnson MA;White KC;Amos JR;Pagano A;Oelze ML;Switzky RD;Wheeler MB;Bethke EB;Shipley CF;Singer AC
通讯作者：
Singer AC
影响因子：
3.5
作者：
Eubank, S.;Eckstrand, I;Barrett, C. L.
通讯作者：
Barrett, C. L.
DOI：
10.1103/physreve.94.062408
发表时间：
2016-12
期刊：
Physical review. E
影响因子：
--
作者：
Parra-Rojas C;House T;McKane AJ
通讯作者：
McKane AJ
影响因子：
120.7
作者：
Grasselli, Giacomo;Zangrillo, Alberto;Pesenti, Antonio
通讯作者：
Pesenti, Antonio