Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone
Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone
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DOI：
10.1128/aac.01609-15
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发表时间：
2016-03-01
影响因子：
4.9
通讯作者：
Crooks, Peter A.
中科院分区：
文献类型：
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作者：
Albayati, Zaineb A. F.;Sunkara, Manjula;Crooks, Peter A.
我们研究了全身静脉给药后万古霉素与一种对羟基磷灰石具有高亲和力的骨靶向制剂(BT)的药代动力学特性。结果证实，与万古霉素相比，Bt-万古霉素在血浆中的持久性增强，在骨中的蓄积增加。这表明，Bt-万古霉素可能是一种潜在的载体，用于全身性靶向输送万古霉素治疗骨感染，潜在地减少了对手术清创的依赖以达到预期的治疗结果。
We examined the pharmacokinetic properties of vancomycin conjugated to a bone-targeting agent (BT) with high affinity for hydroxyapatite after systemic intravenous administration. The results confirm enhanced persistence of BT-vancomycin in plasma and enhanced accumulation in bone relative to vancomycin. This suggests that BT-vancomycin may be a potential carrier for the systemic targeted delivery of vancomycin in the treatment of bone infections, potentially reducing the reliance on surgical debridement to achieve the desired therapeutic outcome.