Metastatic breast lobular carcinoma involving tamoxifen-associated endometrial polyps: Report of two cases and review of tamoxifen-associated polypoid uterine lesions
Metastatic breast lobular carcinoma involving tamoxifen-associated endometrial polyps: Report of two cases and review of tamoxifen-associated polypoid uterine lesions
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DOI：
10.1097/01.mp.0000062655.62606.86
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发表时间：
2003-04-01
期刊：
影响因子：
7.5
通讯作者：
McCluggage, WG
中科院分区：
文献类型：
--
作者：
Houghton, JP;Ioffe, OB;McCluggage, WG
两例小叶乳腺癌转移到子宫内膜息肉的描述。两名患者均接受过他莫昔芬治疗，并出现异常子宫出血。两个病例的子宫内膜活检组织学均显示典型的他莫昔芬相关子宫内膜息肉伴转移性小叶乳腺癌的局灶性细微间质浸润。细胞角蛋白上皮标记物免疫组化染色阳性证实了这一点。转移性乳腺癌可能很少涉及他莫昔芬相关的子宫内膜息肉。由于原发性子宫内膜癌也可能发生在他莫昔芬息肉内，因此应广泛取样。我们简要回顾了可能继发于他莫昔芬治疗的息肉样子宫病变。
Two cases of lobular breast carcinoma metastatic to an endometrial polyp are described. Both patients had been treated with tamoxifen and presented with abnormal uterine bleeding. Histology of endometrial biopsy in both cases showed typical tamoxifen-associated endometrial polyps with focal subtle stromal infiltration by metastatic lobular breast carcinoma. This was confirmed by positive inummohistochemical staining with cytokeratin epithelial markers. Metastatic breast carcinoma may rarely involve tamoxifen-associated endometrial polyps. Because primary endometrial carcinomas may also arise within tamoxifen polyps, these should be extensively sampled. We briefly review polypoid uterine lesions that may occur secondary to tamoxifen therapy.