Burst firing induces a rebound of synaptic strength at unitary neocortical synapses
Burst firing induces a rebound of synaptic strength at unitary neocortical synapses
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DOI：
10.1152/jn.2000.83.1.621
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发表时间：
2000-01-01
影响因子：
2.5
通讯作者：
Hestrin, S
中科院分区：
文献类型：
--
作者：
Galarreta, M;Hestrin, S
高频活动在许多突触上产生短暂的抑制，但最近证明，也可能加速使用依赖性抑制的恢复。我们已经研究了这种突触机制在新皮层兴奋性突触的可能后果，同时记录从突触前锥体神经元和他们的突触后目标。短暂的高频率尖峰脉冲的爆发产生了强烈的抑郁症的单一兴奋性突触后电流（uEPSC）的振幅。然而，当突发放电与低频持续活动相结合时，我们发现强烈的突触抑制之后是突触强度的短暂反弹。这种反弹超过了低频基线值，并持续1-2秒。这些结果表明，在持续活动的存在下，新皮层突触可能在功能上促进以下突发放电。
High-frequency activity produces transient depression at many synapses but also, as recently demonstrated, may accelerate the recovery from use-dependent depression. We have examined the possible consequences of this synaptic mechanism in neocortical excitatory synapses by recording simultaneously from presynaptic pyramidal neurons and their postsynaptic targets. Brief bursts of high-frequency spikes produced a strong depression of the amplitude of unitary excitatory postsynaptic currents (uEPSCs). However, when burst firing was combined with low-frequency ongoing activity, we found that the strong synaptic depression was followed by a transient rebound of synaptic strength. This rebound overshot the low-frequency baseline values and lasted 1-2 s. These results suggest that in the presence of ongoing activity, neocortical synapses may functionally facilitate following burst firing.