Relationship between the unbinding and main transition temperatures of phospholipid bilayers under pressure.
Relationship between the unbinding and main transition temperatures of phospholipid bilayers under pressure.
复制标题
压力下磷脂双层的解结合温度和主转变温度之间的关系。
DOI：
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
J. Katsaras
中科院分区：
文献类型：
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作者：
T. Harroun;M. Nieh;M. Watson;V. Raghunathan;G. Pabst;M. Morrow;J. Katsaras
使用中子衍射和一个专门构造的高压细胞适合对齐的多层膜系统，我们研究了，作为压力的函数，观察到的异常溶胀制度在二肉豆蔻酰和二月桂酰磷脂酰胆碱双层，DMPC和DLPC，分别。我们还重新分析了一些以前发表的实验数据，并得出了以下结论。（一）.幂律行为描述的异常溶胀被保存在所有的PC双层到240 MPa的静水压力。（B）。作为增加压力的函数，存在伴随的DMPC双层的异常溶胀的减少。（c）。对于具有>或=13个碳的烃链的PC脂质，理论未结合转变温度T小星星，填充与主要凝胶到液晶转变温度T（M）耦合。（d）。DLPC本质上不同于所研究的其他脂质，因为它的T小星星，填充不耦合到T（M）。（e）。对于DLPC双层，我们预测可能发生解结合的静水压力（>290 MPa）。
Using neutron diffraction and a specially constructed high pressure cell suitable for aligned multibilayer systems, we have studied, as a function of pressure, the much observed anomalous swelling regime in dimyristoyl- and dilauroyl-phosphatidylcholine bilayers, DMPC and DLPC, respectively. We have also reanalyzed data from a number of previously published experiments and have arrived at the following conclusions. (a). The power law behavior describing anomalous swelling is preserved in all PC bilayers up to a hydrostatic pressure of 240 MPa. (b). As a function of increasing pressure there is a concomitant decrease in the anomalous swelling of DMPC bilayers. (c). For PC lipids with hydrocarbon chains >or=13 carbons the theoretical unbinding transition temperature T small star, filled is coupled to the main gel-to-liquid crystalline transition temperature T(M). (d). DLPC is intrinsically different from the other lipids studied in that its T small star, filled is not coupled to T(M). (e). For DLPC bilayers we predict a hydrostatic pressure (>290 MPa) where unbinding may occur.