Viral Inhibition of BAK Promotes Murine Cytomegalovirus Dissemination to Salivary Glands
Viral Inhibition of BAK Promotes Murine Cytomegalovirus Dissemination to Salivary Glands
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DOI：
10.1128/jvi.02657-12
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发表时间：
2013-03-01
影响因子：
5.4
通讯作者：
Brune, Wolfram
中科院分区：
文献类型：
--
作者：
Handke, Wiebke;Luig, Christina;Brune, Wolfram
细胞凋亡诱导是控制病毒感染的重要宿主防御机制，可被病毒蛋白拮抗。鼠巨细胞病毒 m41.1 编码 BAK 寡聚化病毒抑制剂 (vIBO)，可阻断线粒体凋亡介质 BAK。然而，其对体内病毒适应性的重要性尚未得到研究。在这里，我们发现 m41.1 缺陷型病毒在野生型小鼠的唾液腺中滴度降低，但 Bak1(-/-) 小鼠的唾液滴度却没有降低，这表明需要抑制 BAK 才能在体内实现最佳传播。
Apoptosis induction is an important host defense mechanism to control viral infection, which is antagonized by viral proteins. Murine cytomegalovirus m41.1 encodes a viral inhibitor of BAK oligomerization (vIBO) that blocks the mitochondrial apoptosis mediator BAK. However, its importance for viral fitness in vivo has not been investigated. Here, we show that an m41.1-deficient virus attains reduced titers in salivary glands of wild-type but not Bak1(-/-) mice, indicating a requirement of BAK inhibition for optimal dissemination in vivo.