Lymphoscintigraphy for sentinel node mapping using a hybrid single photon emission CT (SPECT)/CT system in oral cavity squamous cell carcinoma
Lymphoscintigraphy for sentinel node mapping using a hybrid single photon emission CT (SPECT)/CT system in oral cavity squamous cell carcinoma
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DOI：
10.1002/hed.20434
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发表时间：
2006-10-01
影响因子：
2.9
通讯作者：
Even-Sapir, Einat
中科院分区：
文献类型：
--
作者：
Khafif, Avi;Schneebaum, Shlorno;Even-Sapir, Einat
背景资料。我们比较了融合单光子发射计算机断层扫描(SPECT)和低剂量CT图像与平面图像在口腔鳞癌前哨淋巴结(SN)标测中的临床应用价值。20名新诊断为口腔鳞状细胞癌的患者被纳入研究。使用混合伽马相机/低剂量CT系统进行闪烁成像。分别对平面图像和SPECT/CT融合图像进行分析。所有患者均接受了前哨淋巴结活检(SNB)和颈清扫术。除常规病理检查外，所有患者均进行了细致的病理检查和免疫组织化学染色(细胞角蛋白复合体)。检出淋巴结转移的敏感性为87.5%。与平面图像相比，SPECT/CT在6例(30%)患者中改善了SN的识别和/或定位。SPECT/CT SN图为口腔鳞癌患者的SNB提供了更多的临床相关性的术前数据。(C)2006年威利期刊公司。
Background. We assessed the added clinical value of fused single photon emission computed tomography (SPECT) and low-dose CT images compared with planar images for sentinel node (SN) mapping in patients with oral cavity squamous cell carcinoma (SCC).Methods. Twenty consecutive patients with newly diagnosed biopsy-proven SCC of the oral cavity were enrolled. Scintigraphy was performed using a hybrid gamma-camera/low-dose CT system. Planar images and fused SPECT/CT images were interpreted separately. All patients underwent a sentinel node biopsy (SNB) followed by a neck dissection. All SNs underwent meticulous pathologic examination and immunohistochemistry staining (cytokeratin complex) in addition to routine pathologic examinations of the neck dissection specimen.Results. The sensitivity for the detection of nodal metastases was 87.5%. SPECT/CT improved SN identification and/or localization compared with planar images in 6 patients (30%).Conclusions. SPECT/CT SN mapping provides additional preoperative data of clinical relevance to SNB in patients with oral cavity SCC. (c) 2006 Wiley Periodicals, Inc.